The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics / Edition 1

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Overview

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

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Editorial Reviews

Doody's Review Service
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This is a compilation of reviews regarding various aspects of serotonin receptor structure and function.
Purpose: The goal of this book is to provide a comprehensive coverage of all aspects of serotonin receptor structure and function. Given the broad distribution of these molecules, this is a worthwhile objective. The book meets expectations.
Audience: As a set of reviews, the book can be read by a broad scientific audience. Material of interest to senior scientists and research fellows is present. Coverage is timely and the editor has contributions from a broad and capable set of authors.
Features: Serotonin was described first nearly 60 years ago and was rapidly recognized as a molecule with important neurological functions. As the focus naturally shifted towards the molecular targets of serotonin, appreciation of the diversity of these roles became apparent. This book has a set of review articles that cover most features of serotonin receptor structure and function. An initial chapter details the diversity and distribution of these molecules in the animal kingdom (a long table of sequences is provided but hard to read or interpret). This is followed by discussions of structure, cellular location, agonists and antagonists, and signaling functions. Current approaches (proteomics) including work with transgenic animals are also discussed. Each of the chapters is accompanied by a good bibliography of primary references. Investigators wishing an up-to-date review of this field will find this book valuable. Those with selected interest, whether evolutionary or structural, will also find useful material.
Assessment: This is a good, comprehensive set of reviews. As with most volumes from this publisher, illustrations are not top quality. A multipage table of amino acid sequences seems unnecessary. However, overall, it is a valuable book.
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Product Details

  • ISBN-13: 9781588295682
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 6/28/2006
  • Series: Receptors Series
  • Edition description: 2006
  • Edition number: 1
  • Pages: 618
  • Product dimensions: 6.20 (w) x 9.30 (h) x 1.30 (d)

Table of Contents

1 Molecular biology and genomic organization of G protein-coupled serotonin receptors 1
2 Structure and function reveal insights in the pharmacology of 5-HT receptor subtypes 39
3 Polymorphic and posttranscriptional modifications of 5-HT receptor structure : functional and pathological implications 59
4 Strategies for the development of selective serotonergic agents 91
5 5-HT receptor signal transduction pathways 143
6 Agonist-directed trafficking of 5-HT receptor-mediated signal transduction 207
7 Identification of 5-HT[subscript 2] and 5-HT[subscript 4] receptor-interacting proteins : a proteomic approach 237
8 5-HT receptor-associated proteins (FRAPs) : relevance for targeting, trafficking, and signal transduction 257
9 Cellular and subcellular localization of serotonin receptors in the central nervous system 277
10 Chemical neuroanatomy of 5-HT receptor subtypes in the mammalian brain 319
11 Modulation of the neuronal activity and neurotransmitter release by 5-HT[subscript 1A] and 5-HT[subscript 1B/1D] receptors 365
12 Electrophysiology of 5-HT[subscript 2A] receptors and relevance for hallucinogen and atypical antipsychotic drug actions 403
13 The emergence of 5-HT[subscript 2B] receptors as targets to avoid in designing and refining pharmaceuticals 419
14 The 5-HT[subscript 3] receptor 439
15 5-HT[subscript 3] and 5-HT[subscript 4] receptors as targets for drug discovery for dementia 459
16 Electrophysiological properties of G[alpha][subscript s]-coupled 5-HT receptors (5-HT[subscript 4], 5-HT[subscript 6], 5-HT[subscript 7]) 481
17 5-HT[subscript 6] receptors as targets for the treatment of cognitive deficits in schizophrenia 495
18 5-HT[subscript 7] receptors as favorable pharmacological targets for drug discovery 517
19 Serotonin system gene knockouts : a story of mice with implications for man 537
20 Effects of serotonin-related gene deletion on measures of anxiety, depression, and neurotransmission 577
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