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Doody's Review ServiceReviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This is a compilation of reviews regarding various aspects of serotonin receptor structure and function.
Purpose: The goal of this book is to provide a comprehensive coverage of all aspects of serotonin receptor structure and function. Given the broad distribution of these molecules, this is a worthwhile objective. The book meets expectations.
Audience: As a set of reviews, the book can be read by a broad scientific audience. Material of interest to senior scientists and research fellows is present. Coverage is timely and the editor has contributions from a broad and capable set of authors.
Features: Serotonin was described first nearly 60 years ago and was rapidly recognized as a molecule with important neurological functions. As the focus naturally shifted towards the molecular targets of serotonin, appreciation of the diversity of these roles became apparent. This book has a set of review articles that cover most features of serotonin receptor structure and function. An initial chapter details the diversity and distribution of these molecules in the animal kingdom (a long table of sequences is provided but hard to read or interpret). This is followed by discussions of structure, cellular location, agonists and antagonists, and signaling functions. Current approaches (proteomics) including work with transgenic animals are also discussed. Each of the chapters is accompanied by a good bibliography of primary references. Investigators wishing an up-to-date review of this field will find this book valuable. Those with selected interest, whether evolutionary or structural, will also find useful material.
Assessment: This is a good, comprehensive set of reviews. As with most volumes from this publisher, illustrations are not top quality. A multipage table of amino acid sequences seems unnecessary. However, overall, it is a valuable book.