Shock, Sepsis, and Organ Failure: Scavenging of Nitric Oxide and Inhibition of its Production

Overview

At the Sixth Wiggers Bernard Conference, a group of scientists from various disciplines discussed new findings relating to nitric oxide synthase inhibitor in shock, sepsis, and organ failure. Dedicated to the presentation and discussion of both positive and negative findings related to the use of NOS inhibitors, the meeting served as a forum for issues relating to specific and non-specific inhibitors, as well as the role of nitric oxide-oxygen radical interactions. Both experimental and clinical data were ...

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Overview

At the Sixth Wiggers Bernard Conference, a group of scientists from various disciplines discussed new findings relating to nitric oxide synthase inhibitor in shock, sepsis, and organ failure. Dedicated to the presentation and discussion of both positive and negative findings related to the use of NOS inhibitors, the meeting served as a forum for issues relating to specific and non-specific inhibitors, as well as the role of nitric oxide-oxygen radical interactions. Both experimental and clinical data were presented in the trauma and sepsis field.

The book contains black-and-white illustrations.

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Editorial Reviews

David J. Dries
This is a monograph of the edited proceedings and discussion of papers presented at the Sixth Wiggers Bernard Shock Conference. This is a focused review of one of the hot areas in shock research, manipulation of nitric oxide availability in shock. Shock researchers, particularly students of nitric oxide utilization in the setting of shock and resuscitation, will benefit from this monograph. Editors and contributors represent an international group of authorities on this subject. Thirteen presentations with associated discussion are included in the 300 pages of this monograph. Chapters include black-and-white figures and line drawings which reproduce well. Each presentation includes an overview of developments leading up to the topic discussed. The list of references provided with each presentation is extensive. References date to within one to two years of publication for the monograph. No index is provided. Strategies for control of nitric oxide production and nitric oxide scavenging agents are well described. Among the techniques reviewed are use of hemoglobins as nitric oxide scavengers, nitric oxide synthase inhibitors, the relationship of nitric oxide to leukocyte adhesion and microvascular injury, and cytokine control of nitric oxide production. This book shares many of the typical weaknesses of monographs describing proceedings from academic meetings. The presentations tend to be redundant and discussion is sometimes without focus. Nonetheless, for quality of presentation, clarity of figures and tables, and comprehensiveness of reviews and reference lists provided, this monograph, which has been nicely focused, can be warmly recommended.
Doody's Review Service
Reviewer: David J. Dries, MD (University of Minnesota Medical School)
Description: This is a monograph of the edited proceedings and discussion of papers presented at the Sixth Wiggers Bernard Shock Conference.
Purpose: This is a focused review of one of the hot areas in shock research, manipulation of nitric oxide availability in shock.
Audience: Shock researchers, particularly students of nitric oxide utilization in the setting of shock and resuscitation, will benefit from this monograph. Editors and contributors represent an international group of authorities on this subject.
Features: Thirteen presentations with associated discussion are included in the 300 pages of this monograph. Chapters include black-and-white figures and line drawings which reproduce well. Each presentation includes an overview of developments leading up to the topic discussed. The list of references provided with each presentation is extensive. References date to within one to two years of publication for the monograph. No index is provided. Strategies for control of nitric oxide production and nitric oxide scavenging agents are well described. Among the techniques reviewed are use of hemoglobins as nitric oxide scavengers, nitric oxide synthase inhibitors, the relationship of nitric oxide to leukocyte adhesion and microvascular injury, and cytokine control of nitric oxide production.
Assessment: This book shares many of the typical weaknesses of monographs describing proceedings from academic meetings. The presentations tend to be redundant and discussion is sometimes without focus. Nonetheless, for quality of presentation, clarity of figures and tables, and comprehensiveness of reviews and reference lists provided, this monograph, which has been nicely focused, can be warmly recommended.

3 Stars from Doody
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Product Details

  • ISBN-13: 9783642636721
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 4/30/2013
  • Edition description: Softcover reprint of the original 1st ed. 1999
  • Edition number: 1
  • Pages: 293
  • Product dimensions: 6.69 (w) x 9.61 (h) x 0.65 (d)

Table of Contents

Inhibition of the Overproduction of Nitric Oxide in Septic Shock Using N[superscript G]-Methyl-L-Arginine 1
Successful Administration of the NO Synthase Inhibitor 546C88 as a Delayed Continous Infusion in a Baboon Model of Septic Shock 23
Clinical Aspects of Nitric Oxide (NO) Blockade with Pyridoxylated-Hemoglobin Polyoxyethylene Conjugate (PHP) 45
Norepinepherine Versus L-NMMA in Hyperdynamic Septic Shock 69
Roles for Induced Nitric Oxide in Endotoxic and Hemorrhagic Shock 93
Role of Nitric Oxide in the Regulation of Cardiovascular Performance: Clinical Implication for Sepsis and Congestive Heart Failure 119
Inducible NOS and Other Novel Mediators of Inflammation in Brain Trauma 145
Nitric Oxide and Leukocyte Adhesion: Experience with NO Inhibitors, NO Donors and iNOS-Deficient Mice 163
Cytokine Control of Nitric Oxide Production: Therapeutic Possibilities 187
Peroxynitrite: the Dark Side of Nitric Oxide - Effect of Mercaptoethylguanidine (MEG), a Combined Inhibitor of Inducible Nitric Oxide Synthase and Scavenger of Peroxynitrite in Shock, Inflammation, and Ischemia-Reperfusion Injury 203
Actions of Selective and Non-Selective Nitric Oxide Synthase Inhibitors on Multiple-Organ Microvascular Injury Provoked by Lipopolysaccharide 245
Inhibition of Nitric Oxide Synthases by the 4-Amino Analogue of Tetrahydrobiopterin 261
Effects of Nitric Oxide Inhibitors and Hemoglobin in Sepsis 273
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