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Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine / Edition 1

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Distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels.

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Editorial Reviews

Doody's Review Service
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This book offers a set of articles about the signaling properties of several gaseous molecules. Nitric oxide is well known; the others generally less familiar.
Purpose: The goal is to provide a comprehensive review of the state of research in the area of gaseous signaling molecules. Given the wide ranging activities of these modulators, this is an important contribution. The coverage is thorough and goals well met.
Audience: The target audience will include investigators, research fellows, and faculty responsible for teaching in this area. The editor is a recognized authority and has assembled a strong group of authors.
Features: The recognition of nitric oxide as a molecule with regulatory roles changed the view of many with regard to signaling pathways. This book reviews the properties of that molecule (biosynthesis, chemical properties, signaling targets) as well as two close cousins — carbon monoxide and hydrogen sulfide. It is noteworthy that the latter two species have been generally regarded as highly toxic (they are) and among the least likely candidates for normal cellular roles. Most of the actions of these "gasotransmitters" center on ion channels — sodium, potassium and calcium — and clearly have potentially major effects on their targets. An important issue relates to the mechanism of action of each, including the potential for direct chemical modification (nitrosylation, for example) of proteins. The initial chapters provide an overview of the field of gaseous signaling; these are followed by major sections devoted to each of the three. The accompanying bibliographies for each chapter are extensive and provide ample reference to original sources. Laboratories working in almost any area of signal transduction will want to have information regarding this new class of cellular second messengers — a need well served by this book.
Assessment: Although I was aware of the role of nitric oxide, I was unfamiliar with the role of the other molecules covered in this book. I found this to be an important contribution and it is worthwhile reading for most cell biologists and those studying regulation of cellular activities.

3 Stars from Doody
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Product Details

  • ISBN-13: 9781617375125
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/5/2010
  • Edition description: Softcover reprint of hardcover 1st ed. 2004
  • Edition number: 1
  • Pages: 378
  • Product dimensions: 10.00 (w) x 7.00 (h) x 0.81 (d)

Table of Contents

Part I. Gasotransmitters: Past, Present, and Future

The Evolution of Gasotransmitter Biology and Medicine: From Atmospheric Toxic Gases to Endogenous Gaseous Signaling Molecules
Rui Wang

Interactions Between Gasotransmitters
Ray J. Carson, Gunter Seyffarth, Rubina Mian, and Helen Maddock

Part II. The Emergence of the First Gasotransmitter: Nitric Oxide

Nitric Oxide: Synthesis and Metabolism, Tissue Stores, and the Relationship of Endothelium-Derived Nitric Oxide to Endothelium-Dependent Hyperpolarization
Chris R. Triggle, Hong Ding, Ella S. M. Ng, and Anthie Ellis

Chemical Interaction of Nitric Oxide With Protein Thiols: S-Nitrosylation Signaling
Allan Doctor and Benjamin M. Gaston

Nitric Oxide and Adenosine Triphosphate-Sensitive Potassium Channels: Their Different Properties But Analogous Effects on Cellular Protection
Shoji Sanada, Jiyoong Kim, and Masafumi Kitakaze

Interactions of Nitric Oxide and Related Radical Species With KCa Channels
Yanping Liu and David D. Gutterman

Nitric Oxide and Voltage-Gated Ca2+ Channels
Claudio Grassi, Marcello D'Ascenzo, and Gian Battista Azzena

Interactions of Nitric Oxide and Cardiac Ion Channels
Zhao Zhang, Kathryn A. Glatter, and Nipavan Chiamvimonvat

S-Nitrosylation of Cyclic Nucleotide-Gated Channels
Marie-Christine Broillet

Part III. Story of a Silent Killer: The Resurgence of Carbon Monoxide as the Second Gasotransmitter

Synthesis and Metabolism of Carbon Monoxide
Stefan W. Ryter and Augustine M. K. Choi

Interaction of Carbon Monoxide With K+ Channels in Vascular Smooth Muscle Cells
Rui Wang

Modulation of Multiple Types of Ion Channels by Carbon Monoxide in Nonvascular Tissues and Cells
Rui Wang

The Molecular Mechanisms Underlying the Effects of Carbon Monoxide on Calcium-Activated K+ Channels
Lingyun Wu

Carbon Monoxide and Signal Transduction Pathways
Patty J. Lee and Leo E. Otterbein

Carbon Monoxide-Induced Alterations in the Expression of KCa Channels in Pulmonary Artery Smooth Muscle Cells
Eric Dubuis, Prem Kumar, Pierre Bonnet, and Christophe Vandier

Part IV. Gas of the Rotten Egg: Hydrogen Sulfide as Another Gasotransmitter

Hydrogen Sulfide Production and Metabolism in Mammalian Tissues
Kenneth N. Maclean and Jan P. Kraus

Toxicological and Environmental Impacts of Hydrogen Sulfide
Sheldon H. Roth

Hydrogen Sulfide and the Regulation of Neuronal Activities
Hideo Kimura

The Role of Hydrogen Sulfide as an Endogenous Vasorelaxant Factor
Rui Wang, Youqin Cheng, and Lingyun Wu

Hydrogen Sulfide and Visceral Smooth Muscle Contractility
Philip K. Moore

Interaction of Hydrogen Sulfide and Adenosine Triphosphate-Sensitive Potassium Channels in Vascular Smooth Muscle Cells
Rui Wang

Part V. Gasotransmitters, Other Gaseous Molecules, and Cell Metabolism

Gasotransmitters as a Novel Class of Metabolic Regulators: Nitric Oxide, Carbon Monoxide, and Nitrous Oxide
Misato Kashiba


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