Signal Transduction / Edition 1

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Overview

Signal Transduction is a well-illustrated, coherent look at cellular signaling processes. Beginning with the basics, it explains how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and then shows how these inputs are integrated and coordinated. The extensive color artwork provides the reader with a clearer comprehension of key topics, and margin notes are incorporated to highlight milestones in the evolution of signal transduction. This book serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields.

Key Features:
* Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine
* Extensive conceptual colour artwork assists with the comprehension of key topics
* Extensive referencing provides an invaluable link to the core and historical literature
* Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms

Audience: Undergraduate and graduate students in biochemistry, molecular cell biology, cell physiology, pharmacology, and immunology, as well as clinical researchers working in these areas.

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Editorial Reviews

From The Critics
Signal Transduction is indispensable for modern life sciences.
Michael B. Yaffe
The text is strikingly comprehensive...Written with a single voice, the chapters integrate elegantly with one another, and provide the reader with both broad and comprehensive viewpoints...Remarkably current and up-to-date, the book promises to be a core text for graduate and advanced undergraduate courses in cell signaling and molecular cell biology, and a valuable reference book for all scientists whose work involves mechanisms of cell communication.
From The Critics
This textbook examines how the presence of hormones and other intracellular messengers can influence what happens on the inside of their target cells. The European authors describe the mechanisms of cyclic nucleotides and calcium, the covalent modification of proteins and inositol-containing lipids, and their roles in the initiation of intracellular signaling cascades. Annotation c. Book News, Inc., Portland, OR
Doody's Review Service
Reviewer: Alvin Telser, PhD (Northwestern University Feinberg School of Medicine)
Description: This is a basic and comprehensive textbook on the subject of signal transduction.
Purpose: The authors intend the book to be used as a textbook in an advanced undergraduate or graduate course in this subject area. They also state that they hope and expect it will be interesting and useful to scientists at many levels. Signal transduction has become one of the most active and interesting areas of research in modern cell and molecular biology, which makes this book timely and extremely worthwhile. It is very well written and fully meets the author's objectives.
Audience: The major audience for this book are students who will use the book in a formal course on signal transduction, but it has a great deal of important and useful information and is sufficiently well written that many other scientists will find it useful. The authors are very knowledgeable in the subject area.
Features: The book begins with a very interesting historical perspective and proceeds to discuss all the major areas of signal transduction. The authors employ an excellent balance of experimental data and full color schematic diagrams that will greatly assist readers in understanding the material. There are a substantial number of explanatory margin notes that provide definitions, historical background, or points of general interest that add to the interest and understanding of material in the text.
Assessment: This book is an excellent addition to the line of textbooks that are useful for courses in modern cell and molecular biology. The abundant use of graphics is outstanding. The writing is excellent. This should become the standard textbook in the area of signal transduction.
From the Publisher
"Signal Transduction is indispensable for modern life sciences."
-BIOELECTROCHEMISTRY (April 2003)
"...useful to senior undergrad and grad students entering the field, but will also provide a valuable reference for established researchers."
—CELL

5 Stars! from Doody
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Product Details

  • ISBN-13: 9780122896323
  • Publisher: Elsevier Science
  • Publication date: 10/29/2003
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 420
  • Product dimensions: 9.60 (w) x 7.40 (h) x 1.10 (d)

Read an Excerpt

The essential reference to the heart of cell biology
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Table of Contents

Preface
1 Prologue: Signal transduction, origins and personalities 1
2 First messengers 19
3 Receptors 33
4 GTP-binding proteins and signal transduction 71
5 Effector enzymes coupled to GTP-binding proteins: Adenylyl cyclase and phospholipase C 107
6 The regulation of visual transduction 127
7 Calcium and signal transduction 145
8 Calcium signalling 171
9 Phosphorylation and dephosphorylation: Protein kinases A and C 189
10 Growth factors: Setting the framework 225
11 Signalling pathways operated by receptor protein tyrosine kinases 257
12 Signalling pathways operated by non-receptor protein tyrosine kinases 283
13 Phosphoinositide 3-kinases, protein kinase B and signalling through the insulin receptor 299
14 Signal transduction to and from adhesion molecules 315
15 Adhesion molecules and trafficking of leukocytes 345
16 Signalling through receptor bound protein serine/threonine kinases 359
17 Protein dephosphorylation and protein phosphorylation 373
18 Protein domains and signal transduction 393
Index 411
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Sort by: Showing 1 Customer Reviews
  • Anonymous

    Posted July 16, 2002

    Comprehensive, up-date info, and easy to read

    This book gave me a broad specs about what the signal transduction is from historical stand points to therapeutic application. It was very fun to read the history how scientists discovered some growth factors, receptors and so on. This book covers G-protein, Ca signaling, receptor, kinase, phosphatase, cell adhesion signaling, signaling motifs. The format of each chapter looks like Nature Review series, in other words, nice cartoons and a short comment for biological term to understand what that is easily. In addition, this is a comprehensive book and also has up-date information about each signaling pathway.

    Was this review helpful? Yes  No   Report this review
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