Signal Transduction / Edition 2

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Overview

Signal Transduction, 2e, is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction, 2e, serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields.

• Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention
• In-depth coverage of nuclear receptors, including steps in isolation of steroid hormones and the discovery of intracellular hormone receptors; tyrosine protein kinases and adaptive immunity; and intracellular calcium
• Extensive conceptual color artwork to assist with comprehension of key topics
• Instrumental margin notes highlight milestones in signaling mechanisms

Audience: Undergraduate and graduate students in biochemistry, molecular cell biology, cell physiology, pharmacology, and immunology, as well as clinical researchers working in these areas.

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Editorial Reviews

From The Critics
Signal Transduction is indispensable for modern life sciences.
Michael B. Yaffe
The text is strikingly comprehensive...Written with a single voice, the chapters integrate elegantly with one another, and provide the reader with both broad and comprehensive viewpoints...Remarkably current and up-to-date, the book promises to be a core text for graduate and advanced undergraduate courses in cell signaling and molecular cell biology, and a valuable reference book for all scientists whose work involves mechanisms of cell communication.
From The Critics
This textbook examines how the presence of hormones and other intracellular messengers can influence what happens on the inside of their target cells. The European authors describe the mechanisms of cyclic nucleotides and calcium, the covalent modification of proteins and inositol-containing lipids, and their roles in the initiation of intracellular signaling cascades. Annotation c. Book News, Inc., Portland, OR
Doody's Review Service
Reviewer: Alvin Telser, PhD (Northwestern University Feinberg School of Medicine)
Description: This is a basic and comprehensive textbook on the subject of signal transduction.
Purpose: The authors intend the book to be used as a textbook in an advanced undergraduate or graduate course in this subject area. They also state that they hope and expect it will be interesting and useful to scientists at many levels. Signal transduction has become one of the most active and interesting areas of research in modern cell and molecular biology, which makes this book timely and extremely worthwhile. It is very well written and fully meets the author's objectives.
Audience: The major audience for this book are students who will use the book in a formal course on signal transduction, but it has a great deal of important and useful information and is sufficiently well written that many other scientists will find it useful. The authors are very knowledgeable in the subject area.
Features: The book begins with a very interesting historical perspective and proceeds to discuss all the major areas of signal transduction. The authors employ an excellent balance of experimental data and full color schematic diagrams that will greatly assist readers in understanding the material. There are a substantial number of explanatory margin notes that provide definitions, historical background, or points of general interest that add to the interest and understanding of material in the text.
Assessment: This book is an excellent addition to the line of textbooks that are useful for courses in modern cell and molecular biology. The abundant use of graphics is outstanding. The writing is excellent. This should become the standard textbook in the area of signal transduction.
From the Publisher
"Signal Transduction is indispensable for modern life sciences."
-BIOELECTROCHEMISTRY (April 2003)
"...useful to senior undergrad and grad students entering the field, but will also provide a valuable reference for established researchers."
—CELL

5 Stars! from Doody
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Product Details

  • ISBN-13: 9780123694416
  • Publisher: Elsevier Science
  • Publication date: 8/19/2009
  • Edition description: New Edition
  • Edition number: 2
  • Pages: 576
  • Sales rank: 1,416,146
  • Product dimensions: 7.70 (w) x 9.80 (h) x 1.80 (d)

Read an Excerpt

The essential reference to the heart of cell biology
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Table of Contents

Chapter 1 Prologue: Signal Transduction, origins and ancestors
Chapter 2 First messengers
Chapter 3 Receptors
Chapter 4 GTP-binding proteins and signal transduction
Chapter 5 Effector enzymes coupled to GTP binding proteins: adenylyl cyclase and phospholipase C
Chapter 6 The regulation of visual transduction and olfaction
Chapter 7 Intracellular calcium
Chapter 8 Calcium effectors
Chapter 9 Phosphorylation and dephosphorylation: protein kinases A and C
Chapter 10 Nuclear receptors
Chapter 11 Growth Factors: setting the framework
Chapter 12 Signalling pathways operated by receptor protein tyrosine kinases
Chapter 13 Signal transduction to and from adhesion molecules
Chapter 14 Adhesion molecules in the regulation of cell differentiation: Mainly about Wnt
Chapter 15 Activation of the innate immune system: the Toll-like receptor 4 and Signalling through Ubiquitylation
Chapter 16 Traffic of white blood cells
Chapter 17 Tyrosine protein kinases and adaptive immunity : TCR, BCR, soluble tyrosine kinases and NFAT
Chapter 18 Phosphoinositide 3 kinases, protein kinase B and signalling through the insulin receptor
Chapter 19 Protein Kinase C revisited
Chapter 20 Signalling through receptor serine/threonine kinases
Chapter 21 Protein dephosphorylation and protein phosphorylation
Chapter 22 Notch
Chapter 23 Targeting transduction pathways for research and medical intervention
Chapter 24 Protein domains and signal transduction

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