Signal Transduction in Cancer / Edition 1

Signal Transduction in Cancer / Edition 1

by David A. Frank
     
 

ISBN-10: 1402073402

ISBN-13: 9781402073403

Pub. Date: 11/12/2007

Publisher: Springer US

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on

Overview

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents.

Product Details

ISBN-13:
9781402073403
Publisher:
Springer US
Publication date:
11/12/2007
Series:
Cancer Treatment and Research Series, #115
Edition description:
2003
Pages:
357
Product dimensions:
6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

Receptors
1.Growth, Survival and Migration: The Trk to Cancer1
2.The role of growth factor signaling in malignancy19
3.TGF-[beta] Signaling Alterations in Cancer73
4.Notch in Malignancy95
Intracellular Pathways
5.cAMP Signaling in Cancer Genesis and Treatment123
6.PI3K/PTEN/Akt Pathway: A Critical Mediator of
7.Oncogenic Signaling145
8.Wnt signaling in Human Cancer169
9.Ras Signaling, Deregulation of Gene Expression and Oncogenesis189
9.Role of the RB Tumor Suppressor in Cancer209
Transcription Factors
10.The Rel/NF-[kappa]B/I[kappa]B Signal Transduction Pathway and Cancer241
11.STAT Signaling in Cancer: Insights into Pathogenesis and Treatment Strategies267
12.Steroid Hormone Receptor Signaling in Cancer293
Cell Death Pathways
13.Cell Death Signaling in Malignancy319
14.Ceramide and Sphingosine 1-Phosphate in Anti-Cancer Therapies345
Index355

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