Signal Transduction in Cancer / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
$191.78
Used and New from Other Sellers
Used and New from Other Sellers
from $47.89
Usually ships in 1-2 business days
(Save 81%)
Other sellers (Hardcover)
  • All (5) from $47.89   
  • New (2) from $190.73   
  • Used (3) from $47.89   

Overview

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents.
Read More Show Less

Editorial Reviews

From the Publisher
"While the chapters in this book are necessarily brief, all are extensively referenced and msot authors have included historical as well as more recent references. Thus this book is an excellent summary of important signalling pathways in cancer that will be useful for students and researchers. It will serve as a resource for general and specialised knowledge regarding these pathways as well as a platform for more detailed research."
(Cancer Forum, 27:3)
Read More Show Less

Product Details

  • ISBN-13: 9781402073403
  • Publisher: Springer US
  • Publication date: 11/12/2007
  • Series: Cancer Treatment and Research Series , #115
  • Edition description: 2003
  • Edition number: 1
  • Pages: 357
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.81 (d)

Table of Contents

1 Growth, Survival and Migration: The Trk to Cancer 1
2 The role of growth factor signaling in malignancy 19
3 TGF-[beta] Signaling Alterations in Cancer 73
4 Notch in Malignancy 95
5 cAMP Signaling in Cancer Genesis and Treatment 123
6 P13K/PTEN/Akt Pathway: A Critical Mediator of Oncogenic Signaling 145
7 Wnt signaling in Human Cancer 169
8 Ras Signaling, Deregulation of Gene Expression and Oncogenesis 189
9 Role of the RB Tumor Suppressor in Cancer 209
10 The Rel/NF-[kappa]B/I[kappa]B Signal Transduction Pathway and Cancer 241
11 STAT Signaling in Cancer: Insights into Pathogenesis and Treatment Strategies 267
12 Steroid Hormone Receptor Signaling in Cancer 293
13 Cell Death Signaling in Malignancy 319
14 Ceramide and Sphingosine 1-Phosphate in Anti-Cancer Therapies 345
Index 355
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)