Signal Transduction in Cancer / Edition 1

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One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents.
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Editorial Reviews

From the Publisher
"While the chapters in this book are necessarily brief, all are extensively referenced and msot authors have included historical as well as more recent references. Thus this book is an excellent summary of important signalling pathways in cancer that will be useful for students and researchers. It will serve as a resource for general and specialised knowledge regarding these pathways as well as a platform for more detailed research."
(Cancer Forum, 27:3)
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Product Details

  • ISBN-13: 9781402073403
  • Publisher: Springer US
  • Publication date: 11/12/2007
  • Series: Cancer Treatment and Research Series, #115
  • Edition description: 2003
  • Edition number: 1
  • Pages: 357
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.81 (d)

Table of Contents

1 Growth, Survival and Migration: The Trk to Cancer 1
2 The role of growth factor signaling in malignancy 19
3 TGF-[beta] Signaling Alterations in Cancer 73
4 Notch in Malignancy 95
5 cAMP Signaling in Cancer Genesis and Treatment 123
6 P13K/PTEN/Akt Pathway: A Critical Mediator of Oncogenic Signaling 145
7 Wnt signaling in Human Cancer 169
8 Ras Signaling, Deregulation of Gene Expression and Oncogenesis 189
9 Role of the RB Tumor Suppressor in Cancer 209
10 The Rel/NF-[kappa]B/I[kappa]B Signal Transduction Pathway and Cancer 241
11 STAT Signaling in Cancer: Insights into Pathogenesis and Treatment Strategies 267
12 Steroid Hormone Receptor Signaling in Cancer 293
13 Cell Death Signaling in Malignancy 319
14 Ceramide and Sphingosine 1-Phosphate in Anti-Cancer Therapies 345
Index 355
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