Signal Transduction in the Cardiovascular System in Health and Disease / Edition 1

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This book has addressed the contribution of several key signal transduction pathways which are central to our understanding of cardiovascular physiology and pathophysiology. Aberration s in these signaling events have been suggested to be involved in a host of cardiovascular pathologies, such as cardiac arrhythmias, congenital heart failure and hypertension. All the chapters have been writtenh by well known leaders in the fields, which cover a wide range of intracellular events that regulate various aspects of cardiovascular functions. This book will be of interest to both basic as well as clinical scientists seeking to understand the molecular basis of cardiovascular diseases, and also to those interested in defining targets for cardiovascular pharmacotherapy.

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Table of Contents

G-protein coupled receptor signaling.- Implication of G-proteins in cardiovascular diseases.- b-Adrenoceptor-Linked Signal Transduction Mechanisms in Congestive Heart Failure.- Cardiac Ga s and Ga i Modulate Sympathetic Versus Parasympathetic Mechanisms in Hyperhomocysteinemia.- The role of the beta-adrenergic signal transduction pathway in myocardial protection.- Angiotensin II signaling in vascular physiology and pathophysiology.- Angiotensin II signaling: cell growth and apoptosis.- Redox signaling.- Thioredoxin signaling in the ischemic heart.- Relationship between redox regulation and beta- adrenergic resposes in heart.- Role of hypergycemia and redox-induced signaling in vascular complications of diabetes.- Methylglyoxal and Insulin Resistance.- Role of growth factor receptor transactivation in vasoactive peptide induced signalling pathways in Vascular Smooth Muscle Cells.- Identifying the cellular and molecular events associated with the divergent phenotypes of cardiac hypertrophy.- Regulatory role of TGF-b in cardiac myofibroblast function and post-MI cardiac fibrosis: key roles of Smad7 and c-Ski.- The signalling duel between virus and host: impact on coxsackieviral pathogenesis.- Therapeutic Angiogenesis and Vasculogenesis for Ischemic Disease.- VEGF Signaling: A Therapeutic Target for Cardiovascular Diseases.- Myristoyl-CoA:Protein N-Myristoyltransferase and Myristoyl-CoA Binding Protein From Bovine Cardiac Muscle.- Calcium signaling.- Ca2+/Calmodulin-Dependent Protein Kinase II Signaling in Vascular Smooth Muscle.- The KCa3.1 channel in endothelial cells as new traget for an EDHF based control of vascular tone: from structure to regulation and pharmacological properties.- Adipokine signaling.- Leptin signaling in the cardiovascular system.- AMPK regulation of cardiac metabolism in heart disease.

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