Signaling by Toll-Like Receptors

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Overview

The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors.

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Table of Contents

Assessing the Response of Cells to TLR Stimulation, K. Takeda, M. Yamamoto, and K. Honda
TLR Ligands in Experimental Settings: Their Purity and Specificity, M.F.Tsan
Analysis of TLR Expression, Regulation, and Signaling, H. Xiao, X. Li, and D.W. Abbott
Intracellular Trafficking of Toll-Like Receptors, H. Husebye, Ø. Halaas, H. Stenmark, and T. Espevik
The Role of Small RhoGTPases in TLR Signaling, M. Ruse and U.G. Knaus
Use of Engineered β-Lactamase Fragment Complementation to Detect the Associations of Toll-Like Receptors and Signaling Adaptors, H.-K. Lee and P.S. Tobias
Use of Toll-Like Receptor Chimeras to Dissect Mechanisms of Receptor Localization and Signaling, T. Nishiya and A.L. DeFranco
Engagement of Toll-Like Receptors Modulates Chemokine Receptor Signaling, C.-S. Shi and J.H. Kehrl
Role of Toll-Like Receptor Signaling in Central Nervous System Infections, T. Kielian
The Influence of Injury on Toll-Like Receptor Responses, T.J. Murphy, A.A. Maung, H.M. Paterson, and J.A. Lederer
Index

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