Signaling Pathways for Translation: Stress, Calcium, and Rapamycin / Edition 1

Signaling Pathways for Translation: Stress, Calcium, and Rapamycin / Edition 1

by Robert Rhoads
     
 

ISBN-10: 3642075053

ISBN-13: 9783642075056

Pub. Date: 12/10/2010

Publisher: Springer Berlin Heidelberg

This volume presents the response of the eukaryotic translational apparatus to cellular stress and apoptosis, including kinases activated through both the ERK and stress-activated pathways. It further explores two agents that inhibit protein synthesis, calcium and the immunosuppressant rapamycin. Six chapters written by leading experts in the field provide both new

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Overview

This volume presents the response of the eukaryotic translational apparatus to cellular stress and apoptosis, including kinases activated through both the ERK and stress-activated pathways. It further explores two agents that inhibit protein synthesis, calcium and the immunosuppressant rapamycin. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. Both the regulation of initiation and elongation are discussed, and the mechanisms of apoptosis are related to changes in the protein synthesis machinery.

Product Details

ISBN-13:
9783642075056
Publisher:
Springer Berlin Heidelberg
Publication date:
12/10/2010
Series:
Progress in Molecular and Subcellular Biology Series, #27
Edition description:
Softcover reprint of hardcover 1st ed. 2001
Pages:
178
Product dimensions:
6.10(w) x 9.25(h) x 0.24(d)

Table of Contents

The Regulation of eIF4F During Cell Growth and Cell Death.- Regulation of the Activity of Eukaryotic Initiation Factors in Stressed Cells.- Initiation Factor eIF2? Phosphorylation in Stress Responses and Apoptosis.- Elongation Factor-2 Phosphorylation and the Regulation of Protein Synthesis by Calcium.- Phosphorylation of Mammalian eIF4E by Mnk1 and Mnk2: Tantalizing Prospects for a Role in Translation.- Control of Translation by the Target of Rapamycin Proteins.

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