Signaling Pathways In Liver Diseases

Signaling Pathways In Liver Diseases

by J.F. Dufour
     
 

ISBN-10: 3540229345

ISBN-13: 9783540229346

Pub. Date: 06/16/2009

Publisher: Springer-Verlag New York, LLC

Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and…  See more details below

Overview

Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room.

Product Details

ISBN-13:
9783540229346
Publisher:
Springer-Verlag New York, LLC
Publication date:
06/16/2009
Pages:
464
Product dimensions:
1.00(w) x 7.00(h) x 10.00(d)

Table of Contents

Ch. 1Hepatocytes3
Ch. 2Signaling pathways in biliary epithelial cells17
Ch. 3Stellate cells27
Ch. 4Kupffer cells45
Ch. 5Hepatic sinusoidal endothelial cells53
Ch. 6Extracellular matrix63
Ch. 7IL-6/gp130/Stat377
Ch. 8Vascular endothelial growth factor signaling91
Ch. 9Insulin pathway105
Ch. 10Nature and function of hepatic tumor necrosis factor-[alpha] signaling115
Ch. 11The Fas/FasL signaling pathway129
Ch. 12TGF-[beta] and the smad pathway in liver fibrogenesis139
Ch. 13Interferon signaling151
Ch. 14CD14 and toll receptor165
Ch. 15The Wnt/[beta]-catenin pathway173
Ch. 16Notch signaling in liver disease193
Ch. 17Extracellular ATP : emerging roles of purinergic signaling201
Ch. 18Calcium signaling211
Ch. 19MAP kinase pathways in the control of hepatocyte growth, metabolism and survival223
Ch. 20PI3K, PTEN and Akt239
Ch. 21TOR signaling and cell growth control259
Ch. 22Peroxisome proliferator activated receptors267
Ch. 23Transcriptional response to cAMP in the liver281
Ch. 24Heme oxygenase system291
Ch. 25Nitric oxide299
Ch. 26Hypoxia-inducible factor-1 signaling system311
Ch. 27Cyclins and CDKs in liver diseases325
Ch. 28Telomeres and telomerase : distinctive roles in liver regeneration, cirrhosis and carcinogenesis333
Ch. 29NK-[kappa]B341
Ch. 30Ceramide : cell regulation from a lipid perspective353
Ch. 31Apoptosis and mitochondria367
Ch. 32Ubiquitin-proteasome pathway in the pathogenesis of liver disease377
Ch. 33Biological clock in the liver391
Ch. 34Pharmacogenomics of cholestatic liver disease407
Ch. 35Proteomics of signal transduction pathways417

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