BN.com Gift Guide

Signaling Pathways in Liver Diseases

Overview

Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ...

See more details below
This Paperback is Not Available through BN.com
Sending request ...

Overview

Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets for novel therapeutic strategies. It will furthermore stimulate more research and lead to better exchange between the laboratory, the clinical ward and the operation room.

Read More Show Less

Product Details

  • ISBN-13: 9783642061837
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/30/2010
  • Edition number: 1
  • Pages: 442

Meet the Author

Prof. J.-F. Dufour, hepatologist at the University of Bern, is internationally recognized for bridging basic science and clincial practice.
Prof. P.-A. Clavien, head of visceral surgery University Hospital Zürich, is a world renown investigator in the field of liver ischemia/reperfusion injury.
Prof. Clavien successfully lead multi-authored texts having already published 3 books as editor:
Malignant Liver Tumors, Blackwell Science Inc., May 1999
Medical Care of the Liver Transplant Patient (Killenberg/Clavien), Blackwell Science Inc.
Diseases of the Gallbladder and Bile Ducts: Diagnosis and Treatment (Clavien/Baillie),Blackwell Science Inc.
Read More Show Less

Table of Contents

Part I The Cell Types and the Matrix 1

1 Hepatocytes Giuliano Ramadori Pierluigi Ramadori 3

2 Signaling Pathways in Biliary Epithelial Cells M. Fatima Leite Viviane A. Andrade Michael H. Nathanson 25

3 Stellate Cells Fabio Marra Sara Galastri Sara Aleffi Massimo Pinzani 41

4 Signaling Pathways in Liver Diseases Kupffer Cells Christian J. Steib Alexander L. Gerbes 69

5 Hepatic Sinusoidal Endothelial Cells Robert C. Huebert Vijay H. Shah 79

6 Extracellular Matrix Scott L. Friedman 93

7 Platelets: A New Cell Type in Liver Physiology Mickael Lesurtel Pierre-Alain Clavien 105

8 Immune Cell Communication and Signaling Systems in Liver Disease Ricky H. Bhogal Simon C. Afford 117

Part II The Pathways 147

9 Toll-Like Receptors Gyongyi Szabo Pranoti Mandrekar 149

10 TNF/TNF Receptors Jörn M. Schattenberg Mark J. Czaja 161

11 Fas/FasL Maria Eugenia Guicciardi Gregory J. Gores 179

12 Interferon Signaling Markus H. Heim 189

13 NF-κB Tom Luedde Christian Trautwein 201

14 JNKs in liver diseases R. Schwabe 215

15 Insulin Pathway Miran Kim Jack R. Wands 229

16 Role of PKB/Akt in Liver Diseases Elena Zhuravleva Oliver Tschopp Brian A. Hemmings 243

17 Targeting mTOR Signaling Pathways in Liver Diseases Hala E. Thomas Sara C. Kozma 261

18 AMP-Activated Protein Kinase in Liver Louis Hue Laurent Bultot Mark H. Rider 275

19 ER Stress Signaling in Hepatic Injury Cheng Ji Neil Kaplowitz 287

20 PPARα, A Key Regulator of Hepatic Energy Homeostasis in Health and Disease Nicolas Leuenberger Walter Wahli 305

21 Bile Acids and Their Receptors Thierry Claudel Michael Trauner 317

22 Signaling Pathways in Liver Diseases: PXR and CAR Catherine A.M. Stedman Michael Downes Christopher Liddle 333

23 p53 Wen-Wei Tsai Michelle Craig Barton 345

24 The MYC Network and Cancer Snorri S. Thorgeirsson Valentina M. Factor 359

25 The WNT/β-Catenin Pathway Satdarshan P. S. Monga 367

26 Sonic Hedgehog Pathway Alessia Omenetti Anna Mae Diehl 393

27 Hypoxia-Inducible Factor-1 Signaling System Deborah Stroka Daniel Candinas 403

28 VEGF Signaling David Semela Jean-François Dufour 421

29 Apoptosis and Mitochondria Jose C. Fernández-Checa Carmen Garcia-Ruiz 439

30 Calcium Signaling Thierry Tordjmann 455

31 HBV Signaling Massimo Levrero Laura Belloni 465

32 Hepatitis C Virus and Insulin Signaling Francesco Negro Sophie Clément 483

33 MicroRNAs Onpan Cheung Arun J. Sanyal 493

34 Hepatic Clocks Ueli Schibler Gad Asher Camille Saini Jörg Morf Hans Reinke 501

Answers 513

Index 515

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)