Signalling Mechanisms -- from Transcription Factors to Oxidative Stress

Overview

This is a comprehensive account of recent developments in the field of signal transduction mechanisms with an emphasis on calcium, protein kinase C and phospholipases. There is an in-depth coverage of transcription factors responsible for signal transduction from the cytoplasm to the cell nucleus. A special feature of the book is the connection between messenger molecules and free radical reactions and the role of antioxidant defense mechanisms to control these reactions. ...
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Overview

This is a comprehensive account of recent developments in the field of signal transduction mechanisms with an emphasis on calcium, protein kinase C and phospholipases. There is an in-depth coverage of transcription factors responsible for signal transduction from the cytoplasm to the cell nucleus. A special feature of the book is the connection between messenger molecules and free radical reactions and the role of antioxidant defense mechanisms to control these reactions.
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Product Details

  • ISBN-13: 9783642796777
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 1/28/2012
  • Series: Nato ASI Subseries H: (closed) , #92
  • Edition description: Softcover reprint of the original 1st ed. 1995
  • Edition number: 1
  • Pages: 456

Table of Contents

Components of Signal Transduction.- The [Ca2+]i concept: from whole cell to microdomains.- Versatile functions of Ca2+-binding proteins in signal transduction and Ca2+ homeostasis.- Purification of a neurite growth inhibitor (NI-250) from bovine CNS myelin.- Protein kinase C and lipid signalling for cellular regulation.- Phospholipase D regulation in relationship with several protein kinases activation in human neutrophil.- Phosphatide acid phosphohydrolase: its role in cell signalling.- A novel form of type-IVA cAMP phosphodiesterase found in rat brain.- Interaction of the retinal cyclic GMP-phosphodiesterase inhibitor with transducin (Gt) and with other G-proteins (Gi, GO and Gs).- Identification of stable opioid receptor Go-protein complexes using GTP-binding protein selective antisera.- The use of stably transfected cell lines in the analysis of functional interactions between Go?1 & Gi?2 and the—2C10 adrenoceptor.- Modulation of the AMPA/kainate receptors by protein kinase C.- Interaction of MARCKS, a major protein kinase C substrate, with the membrane.- Phosphorylase kinase: a protein kinase for all seasons.- Antioxidants, Oxidative Stress and Hypoxia.- Signal, messenger and trigger molecules from free radical reactions and their control by antioxidants.- Strategies of antioxidant defense: relations to oxidative stress.- Antioxidants: molecular interactions between vitamins E and C, biothiols and carotenes.- Biokinetics of vitamin E in lipoproteins and cells.- Role of mihondria in radical generation and toxicity of—-buty Hydroperoxide towards cultured human endothelial cells.- Hypoxia and endothelial cell adhesiveness.- Hypoxia activates endothelial cells to release inflammatory mediators and growth factors.- Oxidative stress induced by—-interferon and lipopolysaccharide in rat hepayte cultures. Relationship with nitric oxide production.- Effects of nitric oxide on Morris water maze performance in rats: correlation with cGMP levels.- Transcription Factors and Gene Induction.- Signal transduction from the cytoplasm to the cell nucleus by NF-kB/Rel transcription factors.- Functional analysis of the glucocorticoid receptor.- Adipocyte differentiation is dependent on the induction of the acyl-CoA binding protein.- TNF-induced mechanisms for IL6 gene induction.- Regulation of 14 kDa group II PLA2 in rat mesangial cells.- Multifunctional growth factors in morphogenesis and tumor progression.- Gene targeting of the receptor-like protein tyrosine phosphatase LAR by homologous recombination in mouse embryonic stem cells.- Various Functions of Membrane Lipids.- Lipid modifications of eukaryotic proteins: biochemistry and function.- Intracellular synthesis, transport and sorting of glycosphingolipids.- Addendum.- Note to the addendum.- Interleukin 1— and tumor necrosis factor-? modulate the nuclear phosphoinositide signaling system.
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