Signals, Switches, Regulons, and Cascades: Control of Bacterial Gene Expression

by David A. Hodgson (Editor), C. M. Thomas (Editor)

Overview

The use of DNA arrays and proteomics will transform the scale of our ability to describe the patterns of gene expression as bacteria respond to their environments. However, the ability to control bacteria in a clinical context or exploit them in industrial or environmental contexts also depends on understanding the regulatory mechanisms which connect input experience to output response at the genetic level. This book deals with our current knowledge of the circuits and networks that govern bacterial gene expression—from the single gene to the whole genome—and which provide the framework for explaining the data from the post genomics revolution.

Product Details

ISBN-13:	9780521813884
Publisher:	Cambridge University Press
Publication date:	04/18/2002
Series:	Society for General Microbiology Symposia , #61
Pages:	304
Product dimensions:	6.22(w) x 9.33(h) x 0.83(d)

About the Author

David A. Hodgson is a Reader in Microbiology in the Department of Biological Sciences at the University of Warwick.

Christopher M. Thomas is Professor of Molecular Genetics in the School of Biological Sciences at the University of Birmingham.

Table of Contents

Editor's preface; 1. Microbial reaction to environment: bacterial stress responses revisited in the genomic-proteomic era F. C. Neidhardt; 2. Gene variation and gene regulation in bacterial pathogenesis D. Hood and R. Moxon; 3. DNA topology and regulation of bacterial gene expression C. J. Dorman; DNA rearrangements and regulation of gene expression I. C. Blomfield; 4. Structures of multisubunit DNA-dependent RNA polymerases R. D. Finn, E. V. Orlova, M. van Heel and M. Buck; 5. The ECF sigma factors of Streptomyces coelicolor A3(2) M. S. B. Paget, H-J. Hong, M. Bibb and M. J. Buttner; 6. Secrets of bacterial transcription initiation taught by the Escherichia coli FNR protein D. Browning, D. Lee, J. Green and S. Busby; 7. What can be learned from the LacR family of Escherichia coli? B. Muller-Hill; 8. Regulation of the L-arabinose operon in Escherichia coli R. Schleif; 9. Transcription termination control in bacteria T. M. Henkin; 10. Antisense RNAs in programmed cell death K. Gerdes; 11. Control of signal transduction in the sporulation phosphorelay J. A. Hoch; 12. A stranglehold on a transcriptional activator by its partner regulatory protein - the case of the NifL-NifA two-component regulatory system R. Dixon; 13. Is anybody here? Cooperative bacterial gene regulation via peptide signals between Gram-positive bacteria D. A. Morrison; 14. Quorum sensing in Gram-negative bacteria: global regulons controlled by cell-density-dependent chemical signalling N. A. Whitehead, A. K. P. Harris, P. Williams and G. P. C. Salmond; Index.

Editorial Reviews

"...well written and illustrated..." Quarterly Review of Biology

From the Publisher

These 15 papers from the April 2002 conference at Warwick University represent the current state of scientific knowledge related to bacterial gene expression. Specific papers discuss bacterial stress responses, gene variation and regulation, DNA topology, bacterial transcription, , transcription termination control, programmed cell death, signal transduction control, and cooperative bacterial gene regulation. Contributors include microbiologists, biochemists, molecular biologists, pediatricians, immunologists, and other scientists from Europe and the United States. Annotation c. Book News, Inc., Portland, OR (booknews.com)