Skin Delivery Systems: Transdermals, Dermatologicals, and Cosmetic Actives / Edition 1

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This book is a systematic explanation of technologies used to transport drugs and cosmeceuticals through the skin's barriers. After reviewing basic principles of dermatology and skin penetration, the book explains the most current methods of transdermal transport. It covers new materials, such as amphiphilic polymers; formulation methods, e.g., miniemulsions; and variations on technologies such as sonophoresis and iontophoresis. The work also shows the connections between skin penetration and a variety of active substances, including specialized drugs, as well as natural and botanical ingredients used in cosmeceuticals. The book present critical empirical data and design information intended to assist researchers, product developers, and testers in the pharmaceutical and cosmetics industries. Current interest in drug delivery technologies is exceedingly high. Similarly, a recent upsurge in consumer awareness of the potential antiaging and antiwrinkling benefits of natural products and botanicals has spurred a revolution in the cosmetic industry for better skin care delivery technologies, both to preserve inherent activity as well as to enhance their benefits through novel formulation and delivery methods.With these considerations in mind, Skin Delivery Systems: Transdermals, Dermatologicals and Cosmetic Actives brings together the emerging fields of cosmetic actives with new advances in skin delivery technologies and provides a methodical and systematic explanation of technologies used to transport pharmaceuticals and cosmetic actives through the skin's barriers. After reviewing the basic principles of dermatology and skin penetration, the reference describes and explains the most current methods of transdermal transport. Coverage includes new materials, such as amphiphilic polymers; new formulation methods, such as miniemulsions; and variations on technologies such as sonophoresis and iontophoresis. The authors also show the conne

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Product Details

  • ISBN-13: 9780813808482
  • Publisher: Wiley
  • Publication date: 6/12/2006
  • Edition number: 1
  • Pages: 404
  • Product dimensions: 7.30 (w) x 10.30 (h) x 0.90 (d)

Meet the Author

John J. Wille, Ph.D is president of Bioderm Technologies, Inc., a consulting firm in the pharmaceutical and cosmetic industries. Dr. Wille obtained his doctorate in genetics from Indiana University and served as a professor of cell biology at the University of Cincinnati, Louisiana State University and Mayo Medical School, before joining Bristol Myers Squibb as Director of Skin Research. Dr. Wille has published more than 200 research papers and has 15 U.S. patents in the field of skin biology.

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Table of Contents



Section I: General Skin Considerations.

Chapter 1 Fundamental Concepts in Skin Reactivity- John J. Wille and Agis F. Kydonieus.

Chapter 2 Skin Barrier Strategies- Gopinathan Menon and Marie Duggan.

Chapter 3 Abrogation of Skin Reactions: Methods and Agents- John J. Wille and Agis F. Kydonieus.

Chapter 4 Clinical Perspectives on the Efficacy of Cosmetic Actives (Cosmeceuticals)- Emi Dika and Howard I. Maibach.

Section II: Novel Topical Actives .

Chapter 5 Phytocosmeceuticals- John J. Wille.

Chapter 6 Hydroxy Acid Delivery Systems Application for Treatment of Acne- Shyam Gupta.

Chapter 7 Role of Energy Metabolites in Skin Aging and Protection- L. Declercq , Donald Collins, Reyhaneh Foyouzi-Yousseffi, David Gans, Thomas Mammone, Edward Pelle, Kenneth Marenus, Harvey Gedeon, Daniel Maes.

Section III: Trends in Skin Therapy.

Chapter 8 Current Trends in Dermatologicals- Braham Shroot and Donald Aust.

Chapter 9 Topical Treatment of Skin Diseases- Richard S. Kalish.

Chapter 10 Corneotherapy: Novel Topical Treatments of the Stratum Corneum- John J. Wille.

Section IV: Novel Skin Delivery Systems.

Chapter 11 Skin Care Delivery Systems: Overview- Vispi Kanga.

Chapter 12 Emulsions: Factors and Issues in Formulation-Stig Friberg, Zhuning Ma.

Chapter 13 PharmaDur™: Bioadhesive Delivery System- Kishore R. Shah.

Chapter 14 Thixogel: A Starch Matrix Encapsulation Technology and Topical and Cosmetic Delivery- John J. Wille.

Chapter 15 Nanogels in Cosmetics and Personal Care Products- P. Somasundaran, S. Chakraborty, P. Deo, N. Deo, T. Somaqnundaran.

Section V. Transdermal Drug Delivery Technologies.

Chapter 16 Transdermal Drug Delivery Developments: Patent Review- Agis F. Kydonieus and John J. Wille.

Chapter 17 Chemical Enhancers- Rashmi Thakur, Y. Song, Bozena Michniac.

Chapter 18 Accelerated Development of Topical and Transdermal Delivery Systems- Dominic King-Smith and J.M .Newsam.

Chapter 19 Microneedles for Drug and Vaccine Delivery- John Mikszta, M Ishaq Haider, Ronald Pettis.

Chapter 20 Pulsatile “Smart” Drug Delivery- Steven Giannos.

Chapter 21 Microfluidics for Transdermal Drug Delivery- Joseph Huang.

Chapter 22 Future Considerations for Advanced Delivery Systems- Linda R. Rhein.


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