Smith and Williams' Introduction to the Principles of Drug Design and Action

by H. John Smith, Hywel Williams

Overview

Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest informatio

Product Details

ISBN-13:	9781135299750
Publisher:	CRC Press
Publication date:	10/10/2005
Sold by:	Barnes & Noble
Format:	eBook
Pages:	720
File size:	14 MB
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About the Author

H. John Smith, Hywel Williams

Table of Contents

Processes of Drug Handling by the Body. The Design of Drug Delivery Systems. Fundamental Pharmacokinetics. Intermolecular Forces and Molecular Modeling. Drug Chirality and its Pharmacological Consequences. Quantitative Structure–Activity Relationships (QSAR) in Drug Design. Prodrugs. From Program Sanction to Clinical Trials: A Partial View of the Quest for Arimidex, A Potent, Selective Inhibitor of Aromatase. Design of Enzyme Inhibitors as Drugs. Peptide Drug Design. Combinatorial Chemistry: A Tool for Drug Discovery. Recombinant DNA Technology: Monoclonal Antibodies. The Human Genome and its Impact on Drug Discovery and Therapy. The Chemotherapy of Cancer. Neurotransmitters, Agonists, and Antagonists. Design of Antibacterial, Antifungal, and Antiviral Agents. Pharmaceutical Applications of Bioinorganic Chemistry. Index.

Editorial Reviews

The third edition of this textbook provides an introduction to the principles of rational drug design, tracing the process from the bench to the market place. Both novel and established approaches to drug design are considered, and the principles of design are explained using real examples. In addition to updating the contents of the previous edition, Smith (pharmacy, University of Wales) has added sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

This book consists of 17 chapters on a variety of topics related to drug design and action. … This book is intended as a possible text for undergraduate chemistry students interested in medicinal chemistry, or for graduate students as a means to learn the basics of medicinal chemistry. … classical approaches are described for drug design with the inclusion of the more recent context of the human genome project … In summary, some medicinal chemists in academia or the pharmaceutical industry may find this book instructive for certain classes of biomolecules or classical approaches to drug design. It should probably be included in most comprehensive library collections of medicinal chemistry texts and monographs.”
— Bruce L. Currie, Department of Pharmaceutical Sciences, Loma Linda University, California, in Journal of Medicinal Chemistry, , Vol. 50, No. 1, 2007
“The fourth edition of this book includes the latest information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. … real-world examples that illustrate the principles of drug design … New features of this edition include: coverage of agonists and antagonists of neurotransmitters; the design of stable peptide-like drugs; the human genome and its impact on drug discovery and development; advances in therapy and pharmacokinetics.”
— In Anticancer Research, Vol. 26, 2006
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