Smith and Williams' Introduction to the Principles of Drug Design and Action / Edition 3

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Overview

The third edition of this popular textbook builds on the excellent foundations laid down by the earlier editions. It provides a thorough introduction to the principles of rational drug design, adopting a 'from the bench to the market place' approach.
As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated.

The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials

Disc. technical/biological advances; research design & multidisciplinary teams; regulatory environment.

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Editorial Reviews

Booknews
The third edition of this textbook provides an introduction to the principles of rational drug design, tracing the process from the bench to the market place. Both novel and established approaches to drug design are considered, and the principles of design are explained using real examples. In addition to updating the contents of the previous edition, Smith (pharmacy, University of Wales) has added sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9789057022050
  • Publisher: CRC Press
  • Publication date: 4/1/1998
  • Edition description: 3RD
  • Edition number: 3
  • Pages: 568

Table of Contents

Processes of Drug Handling by the Body. The Design of Drug Delivery Systems. Intermolecular Forces and Molecular Modeling. Drug Chirality and its Pharmacological Consequences. Quantitative Structure-Activity Relationships and Drug Design. From Program Sanction to Clinical Trials: A Partial View of the Quest for Arimidex , a Potent, Selective Inhibitor of Aromatase. Pro-Drugs. Design of Enzyme Inhibitors as Drugs. The Chemotherapy of Cancer. Neurotransmitters, Agonists and Antagonists. Design of Antimicrobial Chemotherapeutic Agents. Recombinant DNA technology: Monoclonal Antibodies. Bio-inorganic Chemistry and its Pharmaceutical Applications.

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