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Doody's Review ServiceReviewer: Daniel B. Hier, MD (University of Illinois at Chicago College of Medicine)
Description: This is a collection of presentations and discussions made at the Novartis Symposium held in London during November 2000 on the topic of sodium channels and neuronal hyperexcitability.
Purpose: The primary purpose of the book is to document the proceedings of the symposium. The purpose of the symposium was to gather leading researchers who were examining the problem of the neuronal sodium channel and its relevance to certain human disease states including pain and epilepsy.
Audience: The book is aimed at investigators actively working on the problem of the neuronal sodium channel and its relevance to certain human diseases.
Features: The book consists of 13 presentations on a variety of topics related to the sodium channel. The ensuing symposium discussion after each presentation is reported as is the custom in all of the Novartis Symposium books. Topics covered include mutations of the sodium channel, sodium channel gene expression in epilepsy, relationship of sodium channels to pain states, role of anesthetics in neuropathic pain states, and molecular mechanisms of drug blockade of sodium channels.
Assessment: All the presentations in this book on the sodium channel are at an advanced scientific level and reflect current research on the nature of the neuronal sodium channel and its importance to pain and epilepsy. Each review is well-written but technically complex. The entire book is aimed primarily at the accomplished investigator in the field of neuronal sodium channels. Investigators in the field will find this book extremely valuable.