Sodium Channels and Neuronal Hyperexcitability No. 241 / Edition 1

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Overview

Recent progress has led to a better understanding of the molecular structure of sodium channels, how they work and the mechanisms that restrict their expression to particular cell types.

This book explains how these channels are modulated in various pathological states to enable the development of therapeutic strategies based on sodium channel restoration.

The authors present the most current research on sodium channels and neuronal function.

  • Brings together both the basic biology and biophysics with detailed consideration of the medical applications in chronic pain and epilepsy. 
  • Includes coverage of channelopathies, sodium channel gene expression, the modulation of sodium channels, and molecular mechanisms of gating and drug block of sodium channels.
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Editorial Reviews

From The Critics
Reviewer: Daniel B. Hier, MD (University of Illinois at Chicago College of Medicine)
Description: This is a collection of presentations and discussions made at the Novartis Symposium held in London during November 2000 on the topic of sodium channels and neuronal hyperexcitability.
Purpose: The primary purpose of the book is to document the proceedings of the symposium. The purpose of the symposium was to gather leading researchers who were examining the problem of the neuronal sodium channel and its relevance to certain human disease states including pain and epilepsy.
Audience: The book is aimed at investigators actively working on the problem of the neuronal sodium channel and its relevance to certain human diseases.
Features: The book consists of 13 presentations on a variety of topics related to the sodium channel. The ensuing symposium discussion after each presentation is reported as is the custom in all of the Novartis Symposium books. Topics covered include mutations of the sodium channel, sodium channel gene expression in epilepsy, relationship of sodium channels to pain states, role of anesthetics in neuropathic pain states, and molecular mechanisms of drug blockade of sodium channels.
Assessment: All the presentations in this book on the sodium channel are at an advanced scientific level and reflect current research on the nature of the neuronal sodium channel and its importance to pain and epilepsy. Each review is well-written but technically complex. The entire book is aimed primarily at the accomplished investigator in the field of neuronal sodium channels. Investigators in the field will find this book extremely valuable.
From The Critics
Neurologists and other biological scientists examine the emerging concept that a multiplicity of molecularly and physiologically distinct Na+ channels contribute to neuronal hyperexcitability that can produce clinically significant signs and symptoms. The overall themes that emerge are channel diversity, a very rich biology, molecular and submolecular analysis, pathophysiology, and the pharmacology of sodium channels. Among the 14 specific topics are the multimodal gating of the sodium channel, gene expression and epilepsy, and the modulation of sodium channels in primary afferent neurons. The symposium was held in London in November 2000. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780471485308
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 12/28/2001
  • Series: Novartis Foundation Symposia Series
  • Edition number: 1
  • Pages: 252
  • Product dimensions: 6.24 (w) x 9.37 (h) x 0.67 (d)

Table of Contents

Chair's Introduction: Sodium Channels and Neuronal Dysfunction -
Emerging Concepts, Converging Themes (Stephen G. Waxman).

Studies of Multimodal Gating of the Sodium Channel (Richard D. Keynes).

Molecular Basis for Function in Sodium Channels (Richard Horn).

Diverse Functions and Dynamic Expression of Neuronal Sodium Channels (Stephen G. Waxman, et al.).

Enhanced Transmission of Glutamate Current Flowing from the Dendrite to the Soma in Rat Neocortical Layer 5 Neurons (Wayne E. Crill, et al.).

Mutations of Voltage-gated Sodium Channels in Movement Disorders End Epilepsy (Miriam H. Meisler, et al.).

Channelopathies: Episodic Disorders of the Nervous System (Louis Ptacek).

Sodium Channels Gene Expression and Epilepsy (Jeffrey L. Noebels).

Subunits: Players in Neuronal Hyperexcitability? (Lori L. Isom).

Modulation of Sodium Channels in Primary Afferent Neurons (Stuart Bevan, et al.).

Sodium Channels in Primary Sensory Neurons: Relationship to Pain States (John N. Wood, et al.).

Sodium Channels an Epilepy Electrophysiology (Michael M. Segal).

Therapuetic Concentrations of Local Anaesthetics Unveil the Potential Role of Sodium Channels in Neuropathic Pain (Gary R. Strichartz, et al.).

Molecular Mechanisms of Gating and Drug Block of Sodium Channels (William A. Catterall).

Final General Discussion.

Index of Contributors.

Subject Index.

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