Sphingolipid Metabolism and Cell Signaling, Part B / Edition 1

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More About This Textbook

Overview

This volume contains information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. Its companion Volume 311 presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs.
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Audience: Biochemists, molecular biologists, cell biologists, biomedical researchers, microbiologists, and developmental biologists.

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Editorial Reviews

From the Publisher
Praise for the Series
"The Methods in Enzymology series represents the gold-standard."
--NEUROSCIENCE
"Incomparably useful."
--ANALYTICAL BIOCHEMISTRY
"It is a true 'methods' series, including almost every detail from basic theory to sources of equipment and reagents, with timely documentation provided on each page."
--BIO/TECHNOLOGY
"The series has been following the growing, changing and creation of new areas of science. It should be on the shelves of all libraries in the world as a whole collection."
--CHEMISTRY IN INDUSTRY
"The appearance of another volume in that excellent series, Methods in Enzymology, is always a cause for appreciation for those who wish to successfully carry out a particular technique or prepare an enzyme or metabolic intermediate without the tiresome prospect of searching through unfamiliar literature and perhaps selecting an unproven method which is not easily reproduced."
--AMERICAN SOCIETY OF MICROBIOLOGY NEWS
"If we had some way to find the work most often consulted in the laboratory, it could well be the multi-volume series Methods in Enzymology...a great work."
--ENZYMOLOGIA
"A series that has established itself as a definitive reference for biochemists."
--JOURNAL OF CHROMATOGRAPHY
From the Publisher
Praise for the Series
"The Methods in Enzymology series represents the gold-standard."
—NEUROSCIENCE
"Incomparably useful."
—ANALYTICAL BIOCHEMISTRY
"It is a true 'methods' series, including almost every detail from basic theory to sources of equipment and reagents, with timely documentation provided on each page."
—BIO/TECHNOLOGY
"The series has been following the growing, changing and creation of new areas of science. It should be on the shelves of all libraries in the world as a whole collection."
—CHEMISTRY IN INDUSTRY
"The appearance of another volume in that excellent series, Methods in Enzymology, is always a cause for appreciation for those who wish to successfully carry out a particular technique or prepare an enzyme or metabolic intermediate without the tiresome prospect of searching through unfamiliar literature and perhaps selecting an unproven method which is not easily reproduced."
—AMERICAN SOCIETY OF MICROBIOLOGY NEWS
"If we had some way to find the work most often consulted in the laboratory, it could well be the multi-volume series Methods in Enzymology...a great work."
—ENZYMOLOGIA
"A series that has established itself as a definitive reference for biochemists."
—JOURNAL OF CHROMATOGRAPHY
Eugene A. Davidson
This is Volume 311 in the Methods in Enzymology series. The recognition of lipid second messengers is relatively new and the coverage provided here is a testimonial to the great interest and high activity in this research area. The purpose is to provide full coverage of sphingolipid therapy. The audience for this book ranges from senior investigators to beginning graduate students. The 50 plus chapters can be divided into sections on sphingolipid metabolism and analysis, turnover of key metabolites in the sphingolipid family, genetic tools, and methods for the chemical or enzymatic synthesis of various sphingolipids and derivatives. Since coverage of material directly related to signal transduction is not prominent, it may be presumed that those topics will be covered in a subsequent volume. As with other volumes in this series, the editors and contributors are recognized experts, sufficient detail is presented so as to allow others to follow protocols, and bibliographic coverage is thorough -- all contribute to maintaining the high standards of this series. Although it is convenient to include details of chemical syntheses, these would not be undertaken except by very experienced personnel and thus represent perhaps an unnecessary duplication of material already present in the research literature. Nevertheless, this volume is a must for science or medical libraries and highly desirable for investigators working with this class of compounds.
From The Critics
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This is Volume 311 in the Methods in Enzymology series. The recognition of lipid second messengers is relatively new and the coverage provided here is a testimonial to the great interest and high activity in this research area.
Purpose: The purpose is to provide full coverage of sphingolipid therapy.
Audience: The audience for this book ranges from senior investigators to beginning graduate students.
Features: The 50 plus chapters can be divided into sections on sphingolipid metabolism and analysis, turnover of key metabolites in the sphingolipid family, genetic tools, and methods for the chemical or enzymatic synthesis of various sphingolipids and derivatives. Since coverage of material directly related to signal transduction is not prominent, it may be presumed that those topics will be covered in a subsequent volume.
Assessment: As with other volumes in this series, the editors and contributors are recognized experts, sufficient detail is presented so as to allow others to follow protocols, and bibliographic coverage is thorough:all contribute to maintaining the high standards of this series. Although it is convenient to include details of chemical syntheses, these would not be undertaken except by very experienced personnel and thus represent perhaps an unnecessary duplication of material already present in the research literature. Nevertheless, this volume is a must for science or medical libraries and highly desirable for investigators working with this class of compounds.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780121822132
  • Publisher: Elsevier Science
  • Publication date: 10/30/2000
  • Series: Methods in Enzymology Series
  • Edition number: 1
  • Pages: 688
  • Product dimensions: 1.63 (w) x 9.00 (h) x 6.00 (d)

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