Stability of Insulin / Edition 1

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Overview

A major challenge confronting the pharmaceutical scientist working with protein formulation is the instability during processing, storage and use of the protein drug. This book reviews stability aspects encountered since the pioneering isolation of insulin in 1921. An introductory chapter, treating insulin purity and stability in historical perspective, is followed by a chapter with a description of the structure of insulin.
The main part of the book is a comprehensive review of the literature dealing with stability of insulin in pharmaceutical formulation, including biological stability and the physical and chemical decomposition of insulin. The physical stability (i.e. the tendency of insulin to form insoluble fibrils) is reviewed as are methods to stabilize insulin for long-term use in infusion pumps.
The book will be of interest to research and clinical pharmacologists involved with insulin and other protein-based drug substances.

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Editorial Reviews

Booknews
A thesis presented for the degree of Dr. Pharm. at the Royal Danish School of Pharmacy. It reviews stability aspects encountered since the pioneering isolation of insulin in 1921. The main part of the volume is a comprehensive review of the literature dealing with stability of insulin in pharmaceutical formulation, including biological stability and the physical and chemical decomposition of insulin. The copyright page shows a wrong ISBN (8977-8). Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780792388746
  • Publisher: Springer Netherlands
  • Publication date: 12/14/1994
  • Edition description: 1994
  • Edition number: 1
  • Pages: 132
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.44 (d)

Table of Contents

Introduction 6
I Historical perspective 7
B Early observations relating to stability 7
C Insulin purity 9
II Scenario: structure of the insulin molecule 11
A Primary structure 11
B Secondary and tertiary structure 12
C Quaternary structure (self-association) 12
D Structure of insulin in pharmaceutical formulations 15
III Studies on insulin stability 17
B Biological stability 17
C Physical stability 18
D Chemical stability 23
E Structure-stability relationship 37
Summary and conclusion 37
Resume og konklusion 42
References 46
Reproductions of submitted papers 60
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