Statistical and Computational Pharmacogenomics

Statistical and Computational Pharmacogenomics

by Rongling Wu, Min Lin
     
 

ISBN-10: 1584888288

ISBN-13: 9781584888284

Pub. Date: 07/08/2008

Publisher: Taylor & Francis

Due to the tremendous accumulation of data for genetic markers, pharmacogenomics, the study of the functions and interactions of all genes in the overall variability of drug response, is one of the hottest areas of research in biomedical science. Statistical and Computational Pharmacogenomics presents recent developments in statistical methodology with a

Overview

Due to the tremendous accumulation of data for genetic markers, pharmacogenomics, the study of the functions and interactions of all genes in the overall variability of drug response, is one of the hottest areas of research in biomedical science. Statistical and Computational Pharmacogenomics presents recent developments in statistical methodology with a number of detailed worked examples that outline how these methods can be applied. This comprehensive volume provides key tools needed to understand and model the genetic variation for drug response and equips statisticians with a thorough understanding of this complex field and how computational skills can be employed.

Product Details

ISBN-13:
9781584888284
Publisher:
Taylor & Francis
Publication date:
07/08/2008
Series:
Chapman & Hall/CRC Interdisciplinary Statistics Series
Pages:
368
Product dimensions:
6.40(w) x 9.30(h) x 1.00(d)

Table of Contents

Designs and Strategies for Genomic Mapping and Haplotyping
Genetic Haplotyping in Natural Populations
Genetic Haplotyping in Experimental Crosses
A General Genetic Model for Genetic Haplotyping
Basic Principle of Functional Mapping
Functional Mapping of Pharmacokinetics and Pharmacodynamics
Haplotyping Drug Response with a Pharmacokinetics-Pharmacodynamics
Link Model
Functional Mapping of Biological Clocks
Genetic Mapping of Allometric Scaling
Functional Mapping of Drug Response with Allometric Scaling
Joint Functional Mapping of Drug Efficacy and Toxicity
Modeling Epistatic Interactions in Drug Response
Mapping Genotype-Environment Interactions in Drug Response
Nonparametric Functional Mapping of Drug Response
Semiparametric Functional Mapping of Drug Response
Author Index
Subject Index

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