Statistical and Computational Pharmacogenomics

Hardcover (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $44.00
Usually ships in 1-2 business days
(Save 55%)
Other sellers (Hardcover)
  • All (7) from $44.00   
  • New (6) from $44.00   
  • Used (1) from $123.88   

Overview

Due to the tremendous accumulation of data for genetic markers, pharmacogenomics, the study of the functions and interactions of all genes in the overall variability of drug response, is one of the hottest areas of research in biomedical science. Statistical and Computational Pharmacogenomics presents recent developments in statistical methodology with a number of detailed worked examples that outline how these methods can be applied. This comprehensive volume provides key tools needed to understand and model the genetic variation for drug response and equips statisticians with a thorough understanding of this complex field and how computational skills can be employed.

Read More Show Less

Editorial Reviews

From the Publisher
… a statistically rigorous text that gives a systematic exposition of the subject of pharmacogenomics, the related analytical methods and the corresponding computational algorithms. … a good basis for further methodological, empirical and applied investigation into the field.
Statistics in Medicine, 2011, 30

This text is one of the first books written by statisticians and for statisticians who need to know the basics of genetic markers based on genomic mapping and haplotyping. … this book is a welcome addition that will help me learn pharmacogenomics to the extent that I need it to apply appropriate statistical methodology in microarray analysis and classification problems. … I can recommend it for the statisticians … . I also hope that it will be successful at getting the chemists, biologists, and geneticists interested in the important statistical methods and mathematical modeling described in this book.
—Michael R. Chernick, Technometrics, February 2011

This book covers advanced topics in statistical genetics focusing on applications of interest in pharmacogenomics. The difficulties in estimating haplotype frequencies and their effects on quantitative trait loci (QTLs) are covered in detail for a variety of experimental designs. … of most interest for statisticians working in the pharmaceutical area that need to incorporate genetic variables into consideration in their studies.
ISCB News, No. 50, December 2010

… [Pharmacogenomics] can address questions such as whether individuals with different versions of a gene are more or less likely to respond to a particular drug. However, Wu and Lin go well beyond this and discuss methods for relating genetic variation to dynamic pharmacokinetic and pharmacodynamic profiles of drugs. They refer to this as ‘functional mapping’. … One of the main clinical applications of these methods will be in predicting efficacy and toxicity of drugs, allowing treatment to be tailored to an individual’s genetic background, and this book makes a valuable contribution towards this.
Significance, June 2010

…a volume that can be recommended to both statisticians and life scientists. Yes, there’s plenty of heavy-duty math for the theory lovers, but there are also many sections of explanations for the biologist. These explanations are not highly theoretical and give the scientist a better understanding of what the analysis is doing and why it is needed.
—John A. Wass, Ph.D., Scientific Computing, 2009

Read More Show Less

Product Details

Table of Contents

Designs and Strategies for Genomic Mapping and Haplotyping
Genetic Haplotyping in Natural Populations
Genetic Haplotyping in Experimental Crosses
A General Genetic Model for Genetic Haplotyping
Basic Principle of Functional Mapping
Functional Mapping of Pharmacokinetics and Pharmacodynamics
Haplotyping Drug Response with a Pharmacokinetics-Pharmacodynamics
Link Model
Functional Mapping of Biological Clocks
Genetic Mapping of Allometric Scaling
Functional Mapping of Drug Response with Allometric Scaling
Joint Functional Mapping of Drug Efficacy and Toxicity
Modeling Epistatic Interactions in Drug Response
Mapping Genotype-Environment Interactions in Drug Response
Nonparametric Functional Mapping of Drug Response
Semiparametric Functional Mapping of Drug Response
Author Index
Subject Index

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)