Statistical Bases of Reference Values in Laboratory Medicine / Edition 1

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Overview

Examining the strengths and limitations of various standards of accuracy in clinical laboratory analyses, this detailed reference presents an in-depth study of important theoretical and empirical issues concerning the description, collection, and application of reference values in laboratory medicine.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Earle W. Holmes, PhD (Loyola University Medical Center)
Description: This book presents statistical concepts and practical information concerning the establishment and use of reference values in the clinical laboratory.
Purpose: The book is intended to provide in-depth coverage of some of the newer reference value systems that are expected to play an important role in the future of the field of laboratory medicine.
Audience: It is written primarily for clinical chemists, pathologists, and clinicians but will also be of interest to biostatisticians. Some of the statistical material presented will be too advanced for many of the readers in the primary audience, although the text contains a wealth of practical information that will be understood by all readers.
Features: The book is composed of 10 chapters on topics that include the calculation of reference limits, sample size multivariate reference intervals, time dependent reference intervals, subject-based reference limits and analytical goals. The book contains listings of some useful BASIC computer programs and complete listings of the original data used in many of the sample calculations.
Assessment: This is a significant book that bridges the gap between traditional reference range systems and statistical methods and the newer systems and techniques that represent the wave of the future in the area of reference values. The authors, both of whom are highly regarded in the field of laboratory statistics, have done a thorough job of describing and illustrating the new techniques, and the presentation of these topics in a single, authoritative text makes this book a valuable reference work. The advanced nature of the text (and its high cost) will limit its appeal to the average laboratorian, but it will be an excellent addition to departmental and institutional libraries.
Clinical Chemistry
...The authors...have bridged the gap between the pedantic recitation of statistical dogma and practical application of those tools to the considerable task of establishing appropriate reference values for the analytes we measure...the most significant contribution they make is in relating this application to the real issue in laboratory medicine today: how we can contribute to lowering episode-of-care cost.
Doody's Health Sciences Book Review Journal
...thorough...authoritative...an excellent addition to departmental and institutional libraries.
International Society for Clinical Biostatistics News
...This book is the first book I have seen which covers so much of the area of variation in measurement, and explains it very clearly...essential.
Earle W. Holmes
This book presents statistical concepts and practical information concerning the establishment and use of reference values in the clinical laboratory. The book is intended to provide in-depth coverage of some of the newer reference value systems that are expected to play an important role in the future of the field of laboratory medicine. It is written primarily for clinical chemists, pathologists, and clinicians but will also be of interest to biostatisticians. Some of the statistical material presented will be too advanced for many of the readers in the primary audience, although the text contains a wealth of practical information that will be understood by all readers. The book is composed of 10 chapters on topics that include the calculation of reference limits, sample size multivariate reference intervals, time dependent reference intervals, subject-based reference limits and analytical goals. The book contains listings of some useful BASIC computer programs and complete listings of the original data used in many of the sample calculations. This is a significant book that bridges the gap between traditional reference range systems and statistical methods and the newer systems and techniques that represent the wave of the future in the area of reference values. The authors, both of whom are highly regarded in the field of laboratory statistics, have done a thorough job of describing and illustrating the new techniques, and the presentation of these topics in a single, authoritative text makes this book a valuable reference work. The advanced nature of the text (and its high cost) will limit its appeal to the average laboratorian, but it will be an excellent addition to departmentaland institutional libraries.
Booknews
Identifies and addresses important topics relating to the reference values in laboratory medicine, the standards against which any measurement from an individual patient must be compared to have significance. Reviews methods for deriving population- based reference ranges or other indices that involve a combination of biological variation among and within individuals and analytical variation due to measurement error. With slight changes in focus, then examines the biological and analytical components of variations within individuals and the analytical element in relation to the within-subject biological variation. A final chapter suggests the direction of the field into electronic records, automation, and molecular genetics. Primarily addressed to clinical chemists, pathologists, and clinicians, and so includes some elementary information about statistics; also includes however some advanced statistical material that should hold the interest of practicing biostatisticians and give the primary readers a sense of what is beyond their current or desired knowledge. Annotation c. Book News, Inc., Portland, OR (booknews.com)

4 Stars! from Doody
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Product Details

Table of Contents

Some History of Reference Values

Calculating Reference Limits

Sample Sizes and Subgroups

Multivariate Reference Regions and Indices

Time-Dependent Reference Values

Comparison of Within-Subject and Among-Subject Variances

Predictive Values for Monitoring Healthy Subjects and Patients

Analytical Goals for Reference Values

Analytical Goals In Therapeutic Drug Monitoring

Reference Values in the Future

References

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