Statistical Genetics of Quantitative Traits: Linkage, Maps and QTL / Edition 1

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Overview

Includes a detailed description of a number of statistical approaches and the step-by-step demonstration of live-example analyses designed to explain the utilization and usefulness of statistical methods The book contains exercise sets and computer codes for all the analyses used, giving graduates and senior undergraduates a deeper understanding of the methodology Provides statistical models and analytical procedures for detecting specific genes, enabling readers to use the book as a practical tool Concentrates on the linkage analysis of markers, map construction and quantitative trait locus (QTL) mapping The book introduces the basic concepts and methods that are useful in the statistical analysis and modeling of DNA-based marker and phenotypic data that arise in agriculture, forrestry, experimental biology, and other fields. It concentrates on the linkage analysis of markers, map construction and quantitative trait locus (QTL) mapping and assumes a background in regression analysis and maximum likelihood approaches. The strengths of this book lie in the construction of general models and algorithms for linkage analysis and QTL mapping in any kind of crossed pedigrees initiated with inbred lines of crops and plant and animal model systems or outbred lines in forest trees and wildlife species. The book includes a detailed description of each approach and the step-by-step demonstration of live-example analyses designed to explain the utilization and usefulness of statistical methods. The book also includes exercise sets and computer codes for all the analyses used. This book can serve as a textbook for graduates and senior undergraduates in genetics, agronomy, forest biology, plant breeding and animal sciences. It will also be useful to researchers and other professionals in the areas of statistics, biology and agriculture. Rongling Wu is Associate Professor of Statistics at the University of Florida, Gainesville. He currently serv

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Editorial Reviews

From the Publisher

From the Reviews:

"[I]t is a big help and guidance in the field of statistical developments for genetic mapping, synthesised all in one volume helping to build a bridge between genetics and statistics." (Lutz Bunger, Genetic Research, 89, 2007)

"...[T]his is an ideal book for a young researcher looking for an exciting and developing field to get into." (International Statistics Review, April 2008)

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Product Details

  • ISBN-13: 9780387203348
  • Publisher: Springer New York
  • Publication date: 7/28/2007
  • Series: Statistics for Biology and Health Series
  • Edition description: 2007
  • Edition number: 1
  • Pages: 368
  • Product dimensions: 6.78 (w) x 9.44 (h) x 0.87 (d)

Table of Contents

Basic Genetics.- Basic Statistics.- Linkage Analysis and Map Construction.- A General Model for Linkage Analysis in Controlled Crosses.- Linkage Analysis with Recombinant Inbred Lines.- Linkage Analysis for Distorted and Misclassified Markers.- Special Considerations in Linkage Analysis.- Marker Analysis of Phenotypes.- The Structure of QTL Mapping.- Interval Mapping with Regression Analysis.- Interval Mapping by Maximum Likelihood Approach.- Threshold and Precision Analysis.- Composite QTL Mapping.- QTL Mapping in Outbred Pedigrees.

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