Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix

Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix

by Earl Prohofsky
     
 

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ISBN-10: 0521451841

ISBN-13: 9780521451840

Pub. Date: 07/28/1995

Publisher: Cambridge University Press

This book develops a statistical mechanical analysis of the stability of biological macromolecules. It develops a new theoretical approach for executing macromolecule calculations. In particular the author devises a method for describing chemical bond disruption in these large systems, which are then used to determine when the helix melts and how drugs can dissociate

Overview

This book develops a statistical mechanical analysis of the stability of biological macromolecules. It develops a new theoretical approach for executing macromolecule calculations. In particular the author devises a method for describing chemical bond disruption in these large systems, which are then used to determine when the helix melts and how drugs can dissociate from the helix. The book will be of interest to biomolecular dynamics researchers, especially graduate students in biological physics, theoretical chemistry and molecular biology.

Product Details

ISBN-13:
9780521451840
Publisher:
Cambridge University Press
Publication date:
07/28/1995
Pages:
240
Product dimensions:
5.98(w) x 8.98(h) x 0.63(d)

Table of Contents

Preface; 1. Introduction; 2. Macromolecular stability; 3. Lattice dynamics; 4. Effective phonon theory; 5. Premelting disrupted chemical bonds; 6. Co-operative melting; 7. Strained chemical bonds: salt and pressure effects; 8. Bond disruption and conformation change: B to Z confirmation change in DNA; 9. Hydration effects: structural water; 10. Helix with daunomycin intercalated: increased helix stability and daunomycin-DNA bonding constant; 11. Non repeating DNA; 12. Cutting and splicing: junctions, inserts and the replicating fork; 13. Interaction between a helix and a single attached molecule; 14. Energy considerations in bond opening; Appendix 1; Appendix 2; Appendix 3. Index

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