Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix

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This book develops a statistical mechanical analysis of the stability of biological macromolecules. It develops a new theoretical approach for executing macromolecule calculations. In particular the author devises a method for describing chemical bond disruption in these large systems, which are then used to determine when the helix melts and how drugs can dissociate from the helix. The book will be of interest to biomolecular dynamics researchers, especially graduate students in biological physics, theoretical chemistry and molecular biology.
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Editorial Reviews

Develops a statistical mechanical analysis of the stability of biological macromolecules that is valid both for the long time scale needed for DNA bond disruption and for the highly cooperative transitions needed to explain helix melting. Devises a method for describing chemical bond disruption in such systems, and uses that to determine when the helix melts and how drugs can dissociate from the helix. Then shows how to account for environmental variables and how to perform calculations on specific structures embedded in a large helix and on the dynamic effects of enzyme attachments. For researchers and graduate students in biological physics, theoretical chemistry, and molecular biology. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780521451840
  • Publisher: Cambridge University Press
  • Publication date: 7/28/2005
  • Pages: 240
  • Product dimensions: 5.98 (w) x 8.98 (h) x 0.63 (d)

Table of Contents

1 Introduction 1
2 Macromolecular stability 17
3 Lattice dynamics 47
4 Effective phonon theory 60
5 Premelting disrupted chemical bonds 78
6 Cooperative melting 88
7 Strained chemical bonds: salt and pressure effects 103
8 Bond disruption and conformation change: B to Z conformation change in DNA 117
9 Hydration effects: structural water 127
10 Helix with daunomycin intercalated: increased helix stability and daunomycin-DNA binding constant 137
11 Nonrepeating DNA 146
12 Cutting and splicing: junctions, inserts, and the replicating fork 159
13 Interaction between a helix and a single attached molecule 173
14 Energy considerations in bond opening 181
Appendix 1. Helical lattice dynamics 193
Appendix 2. Density matrix and effective phonon theory 199
Appendix 3. Green functions 206
References 214
Index 223
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