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Doody's Review ServiceReviewer: Parthiv Amin, MD (East Tennessee State University Quillen College of Medicine)
Description: This novel book provides an introduction to the various statistical methods that define the development of dynamic treatment regime, an important component of the newly evolving idea of personalized medicine. The chapter authors are experts in their fields and take a keen interest in developing the concept of personalized medicine.
Purpose: The purpose is to focus on personalized medicine and various study designs as well as statistical methods to develop evidence-based, personalized treatments for patients with chronic disease. It provides a comprehensive overview of dynamic treatment regimes, which is an important segment of personalized medicine. Ultimately, it has been shown that personalized medicine will improve patient compliance and improve outcomes of treatment for various chronic diseases.
Audience: The intended audience includes physicians, clinical researchers, physicians in training, statisticians, and medical students, as well as master's and doctoral students in the field of biostatistics and epidemiology and computer scientists.
Features: The book is well structured with the initial two chapters providing an introduction to personalized medicine and dynamic treatment regimens. The subsequent chapters describe the science of mathematics and various statistical methods. Each chapter has numerous clinically based data examples that precisely explain the different statistical methods. With extensive graphs and tables, the authors have done an excellent job of providing a concise and simple approach to learning complicated statistical methods. The utility of each method as well as a summation is provided in each chapter, which makes conceptualization easy.
Assessment: This book provides a concise summary of the key findings in the statistical literature of dynamic treatment regimes. Personalized medicine is a fast evolving branch of medicine and this book explains the various methods involved in the development of regimes. The simple language and well-organized chapters are unsurpassed attributes of this book. It will be an exceptional resource for quick review.