Statistical Methods in Analytical Chemistry / Edition 1

Statistical Methods in Analytical Chemistry / Edition 1

by Peter C. Meier, Richard E. Zund
     
 

ISBN-10: 0471584541

ISBN-13: 9780471584544

Pub. Date: 04/12/1993

Publisher: Wiley

This book provides you with practical information on the use of statistical methods for solving real-world problems in complex industrial environments. Complete with examples from the chemical and pharmaceutical laboratory and manufacturing areas, this thoroughly updated book clearly demonstrates how to obtain reliable results by choosing the most appropriate…  See more details below

Overview

This book provides you with practical information on the use of statistical methods for solving real-world problems in complex industrial environments. Complete with examples from the chemical and pharmaceutical laboratory and manufacturing areas, this thoroughly updated book clearly demonstrates how to obtain reliable results by choosing the most appropriate experimental design and data evaluation methods." "Statistical Methods in Analytical Chemistry, Second Edition is a resource for laboratory scientists and engineers and project managers who need to assess data reliability; QC staff, regulators, and customers who want to frame realistic requirements and specifications; as well as educators looking for real-life experiments and advanced students in chemistry and pharmaceutical science.

Product Details

ISBN-13:
9780471584544
Publisher:
Wiley
Publication date:
04/12/1993
Series:
Chemical Analysis: A Series of Monographs on Analytical Chemistry and Its Applications Series, #181
Edition description:
BOOK/DISK
Pages:
344
Product dimensions:
6.18(w) x 9.22(h) x 0.94(d)

Table of Contents

Preface
Chemical Analysis Series
Introduction1
Ch. 1Univariate Data13
1.1Mean and Standard Deviation13
1.2Distributions and the Problem of Small Numbers29
1.3Confidence Limits35
1.4The Simulation of a Series of Measurements41
1.5Testing for Deviations44
1.6Number of Determinations65
1.7Width of a Distribution69
1.8Charting a Distribution74
1.9Errors of the First and Second Kind87
Ch. 2Bi- and Multivariate Data91
2.1Correlation92
2.2Linear Regression94
2.3Nonlinear Regression127
2.4Multidimensional Data/Visualizing Data132
Ch. 3Related Topics137
3.1GMP Background: Selectivity and Interference/Linearity/Accuracy/Precision/Reliability/Economic Considerations137
3.2Development, Qualification, and Validation; Installation Qualification, Operations Qualification, Performance Qualification/Method Development/Method Validation140
3.3Data Treatment Scheme: Data Acquisition/Acceptance Criteria/Data Assembly and Clean-up/Data Evaluation/Presentation of Results/Specifications/Records Retention145
3.4Exploratory Data Analysis (EDA)148
3.5Optimization Techniques149
3.6Smoothing and Filtering Data/Box-Car Averaging/Moving Average/Savitzky-Golay Filtering/CUSUM167
3.7Error Propagation and Numerical Artifacts169
3.8Programs171
Ch. 4Complex Examples175
4.1To Weight or Not to Weigh175
4.2Nonlinear Fitting180
4.3UV-Assay Cost Structure185
4.4Process Validation190
4.5Regulations and Realities193
4.6Diffusing Vapors199
4.7Stability a la Carte202
4.8Secret Shampoo Switch203
4.9Tablet Press Woes205
4.10Sounding Out Solubility208
4.11Exploring a Data Jungle210
4.12Sifting Through Sieved Samples215
4.13Controlling Cyanide221
4.14Ambiguous Automation225
4.15Mistrusted Method229
4.16Quirks of Quantitation230
4.17Pursuing Propagating Errors235
4.18Content Uniformity237
4.19How Full Is Full?240
4.20Warranty or Waste245
4.21Arrhenius-Abiding Aging249
4.22Facts of Artifacts?251
4.23Proving Proficiency254
4.24Gotta Go Gambling263
4.25Does More Sensitivity Make Sense?277
4.26Pull the Brakes!279
4.27The Limits of Nonlinearities280
4.28The Zealous Statistical Apprentice283
4.29Not Perfect, but Workable288
4.30Complacent Control291
4.31Spring Cleaning295
4.32It's All a Question of Pedigree304
4.33New Technology Rattles Old Dreams308
4.34Systems Suitability310
4.35An Eye Opener311
4.36Boring Bliss313
4.37Keeping Track of Dissolving Tablets317
4.38Poking Around in the Fog319
Ch. 5Appendices329
5.1Numerical Approximations to Some Frequently Used Distributions329
5.2Core Instructions Used in Several Programs339
5.3Installation and Use of Programs on Diskette339
5.4Program and Data File Description361
Technical Tidbits399
Glossary401
References404
Index417

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