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Stem Cell and Gene-Based Therapy: Frontiers in Regenerative Medicine / Edition 1

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Overview

Regenerative medicine - stem cell and gene-based therapy - provides a new clinical approach for restoring function of damaged organs and tissues. There has been incredible progress in experimental strategies for tissue regeneration, particularly in cell transplantation and stem cell research. These have led to potential treatment options for many otherwise fatal conditions, including end-stage organ failure. Cell therapy and tissue engineering of viable grafts could therefore provide prospective new solutions to the serious problems of organ donor shortage.

Stem Cell and Gene-Based Therapy: Frontiers in Regenerative Medicine is written by the leading figures in the field of stem cells, gene therapy and tissue engineering and covers the major approaches to regenerative medicine, ensuring that techniques learnt in one discipline are disseminated across other areas of medicine. This allows practitioners to gain knowledge not only of how regenerative medicine applies to their own discipline directly but also how it will benefit their patients in the years to come. Consequently, the multidisciplinary nature of the book appeals to students, scientists and clinicians from a wide spectrum of disciplines, including cardiology, pulmonology, neurology, ophthalmology, orthopedics, and dermatology.

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Editorial Reviews

Doody's Review Service
Reviewer: Bruce A. Fenderson, PhD (Thomas Jefferson University)
Description: Stem cell researchers hope to discover the genetic and biochemical pathways that direct cell differentiation and histogenesis. Their goal is to replace injured tissues in patients with chronic diseases such as myocardial infarction, diabetes mellitus, and Parkinson disease. This beautiful hard-cover book provides an overview of recent progress in this field. It includes 28 chapters on topics ranging from "myocardial tissue repair" and "wound healing and skin substitutes," to "tissue engineering the bladder." The primary focus is on cell biology and bioengineering.
Purpose: According to the editors, the aim of this book is to "cover key aspects of the promise and existing problems in the emerging field of regenerative medicine." They hope the book "will provide a realistic image of the huge potential, promise, and challenges facing the fantastic field of regenerative medicine in its quest to cure disease and prolong life.
Audience: The book is written primarily for basic science and clinical researchers (graduate students, postdoctoral fellows, scientists) interested in both adult and embryonic stem cells. Biomedical researchers interested in gene therapy, molecular pathology, and developmental biology will also value this book because of its clinically-relevant approach (from bench to bedside).
Features: The book is divided into eight major sections, which focus on different populations of stem cells (e.g., kidney, pancreas, skin). Each section begins with an insightful overview of the organ system and its response to injury. The authors organize the literature to make each chapter a story that educates and reads well. Each chapter provides an introduction, headers to focus the reader's attention, and a comprehensive list of references. The tables and 62 figures are informative. The book includes glossy pages and 27 beautiful, full-color plates that illustrate breakthroughs in cell engineering. The book is carefully edited and the authors are experts.
Assessment: The book provides an up-to-date synthesis of information regarding cell engineering and regenerative medicine. A major strength of this book is that the authors are interested in clinical applications of their basic research. The examples and illustrations are well done. The broad scope of topics will attract attention from the entire biomedical research community. The book provides a snap shot of current research, a vision of research opportunities, and hope for patients with chronic diseases.
From The Critics
Reviewer: Bruce A. Fenderson, PhD(Thomas Jefferson University)
Description: Stem cell researchers hope to discover the genetic and biochemical pathways that direct cell differentiation and histogenesis. Their goal is to replace injured tissues in patients with chronic diseases such as myocardial infarction, diabetes mellitus, and Parkinson disease. This beautiful hard-cover book provides an overview of recent progress in this field. It includes 28 chapters on topics ranging from "myocardial tissue repair" and "wound healing and skin substitutes," to "tissue engineering the bladder." The primary focus is on cell biology and bioengineering.
Purpose: According to the editors, the aim of this book is to "cover key aspects of the promise and existing problems in the emerging field of regenerative medicine." They hope the book "will provide a realistic image of the huge potential, promise, and challenges facing the fantastic field of regenerative medicine in its quest to cure disease and prolong life."
Audience: The book is written primarily for basic science and clinical researchers (graduate students, postdoctoral fellows, scientists) interested in both adult and embryonic stem cells. Biomedical researchers interested in gene therapy, molecular pathology, and developmental biology will also value this book because of its clinically-relevant approach (from bench to bedside).
Features: The book is divided into eight major sections, which focus on different populations of stem cells (e.g., kidney, pancreas, skin). Each section begins with an insightful overview of the organ system and its response to injury. The authors organize the literature to make each chapter a story that educates and reads well. Each chapter provides an introduction, headers to focus the reader's attention, and a comprehensive list of references. The tables and 62 figures are informative. The book includes glossy pages and 27 beautiful, full-color plates that illustrate breakthroughs in cell engineering. The book is carefully edited and the authors are experts.
Assessment: The book provides an up-to-date synthesis of information regarding cell engineering and regenerative medicine. A major strength of this book is that the authors are interested in clinical applications of their basic research. The examples and illustrations are well done. The broad scope of topics will attract attention from the entire biomedical research community. The book provides a snap shot of current research, a vision of research opportunities, and hope for patients with chronic diseases.
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Product Details

  • ISBN-13: 9781852339791
  • Publisher: Springer London
  • Publication date: 9/27/2007
  • Edition description: 2006
  • Edition number: 1
  • Pages: 422
  • Product dimensions: 1.00 (w) x 10.00 (h) x 7.00 (d)

Table of Contents

Heart: Introduction.- Renovation of the Injured Heart with Myocardial Tissue Engineering.- Adult Stem Cells for Myocardial Tissue Repair.- Regeneration of the Functional Myocardium Using Human Embryonic Stem Cells.- Therapeutic Angiogenesis.- Cell Therapy for Heart Failure.- Neuro: Introduction.- Cell Transplantation for Diseases of Myelin.- Stem Cells as a Source for Cell Replacement in Parkinson’s Disease.- Cell Replacement Therapy in Acute Stroke: Current State.- Gene Therapy to the Nervous System.- Musculoskeletal: Introduction.- Mesenchymal Stem Cells: Where Can You Find Them? How Can You Use Them?- Basic to Clinical Cartilage Engineering, Past, Present and Future Discussions.- Cartilage.- Bone Regeneration.- Osteoarthritis and Mesenchymal Cells – The Prospects for Repair of the Disease by Cell Transplantation and Tissue Engineering.- Kidney.- Introduction.- Progenitor Cell Therapy for Kidney Regeneration.- Tissue Engineering: The Bladder.- Eye.- Introduction.- Neuroprotection in Ophthalmology: A Review.- Autoimmunity for CNS Maintenance, Regeneration and Renewal: Development of a T Cell-Based Vaccination Against Neurodegeneration.- Retinal Repair by Stem Cell Transplantation.- Induction of Ocular Surface Regeneration.- Pancreas.- Introduction.- Insulin-Producing Cells Generated from Non-Pancreatic Tissues Islets from Pancreatic Progenitor Cells (Duct, Islet, and Exocrine).- Generation of Islets from Pancreatic Progenitor Cells.- Embryonic Stem Cells as a Source of Pancreatic Precursors and Islet Cells in Vitro.- Hematology.- Introduction.- Human Umbilical Cord Blood Transplantation: A viable Option for Stem Cell Graft.- Nonmyeloablative Stem-Cell Transplantation in the Treatment of Hematological Malignancies.- Haematopoietic Stem Cell Transplantation from HLA Haploidentical Donor.- Skin.- Introduction.- Wound Healing and Skin Substitutes.- Skin Regeneration From Multipotent Adult and Embryonic Stem Cells.
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