Stem Cell and Liver Regeneration / Edition 1

by K. Okita

Overview

Cellular therapy with liver stem cells and their progeny, including bone marrow cells, is a promising new approach that will contribute significantly to the treatment of liver diseases. The existence of the liver stem cell had long been debated, but it is now generally accepted that the liver contains cells with stem-like properties and that these cells can be activated to proliferate and differentiate into mature hepaytes under certain conditions. There is also a substantial body of evidence to suggest that oval cells are involved in liver regeneration as they differentiate into hepaytes and biliary cells. This book is a collection of work on stem cell and liver regeneration, initially delivered at the 14th Yamaguchi (Japan) Symposium on Liver Disease. Its nine chapters present the most recent data about basic and clinical research in hepatology in Japan and other countries, providing a valuable resource for researchers and practitioners alike.

Product Details

ISBN-13:	9784431401995
Publisher:	Springer Japan
Publication date:	01/08/2004
Series:	Frontiers in Hepatology
Edition description:	2004
Pages:	87
Product dimensions:	6.10(w) x 9.25(h) x (d)

Table of Contents

SAPK/JNK Signaling Participates in Embryonic Hepatoblast Proliferation via a Pathway Different from NF-κB-Induced Anti-Apoptosis.- Promising Resources of Hepatic Progenitor Cells.- Oncostatin M Promotes Differentiation of Fetal Hepaytes in vitro and Regulates Liver Regeneration in vivo.- Hepayte Growth Factor Accelerates Proliferation of Hepatic Oval Cells in a 2-Acetylaminofluorene/Partial Hepatectomy Model in the Rat.- Stem Cells and Liver Repopulation: Current Reality and Prospects for the Future.- Strategy for the Development of Cell Therapy Using Bone Marrow Cells to Repair Damaged Liver.- Bcl-xL as a Critical Apoptosis Antagonist in Hepaytes and Hepaellular Carcinoma.- Dedifferentiation and Proliferation of Hepaellular Carcinoma: From Early to Advanced.- Genome-Wide Analysis of Gene Expression in Hepaellular Carcinoma.