Stem Cell Biology / Edition 1

Paperback (Print)
Buy New
Buy New from BN.com
$149.95
Used and New from Other Sellers
Used and New from Other Sellers
from $2.00
Usually ships in 1-2 business days
(Save 98%)
Other sellers (Paperback)
  • All (13) from $2.00   
  • New (9) from $61.11   
  • Used (4) from $2.00   

Overview

Stem cells have generated considerable interest recently in the scientific, clinical, and public arenas. It is essential that we gain a broader understanding of the factors that regulate the biology of stem cells: their ability for self-renewal, differentiation, and plasticity, as well as the differences between embryonic and adult stem cells. And to learn whether stem cells can be manipulated to replace cells in diseased tissues depends on better understanding their normal developmental properties.

This volume offers contributions from numerous interdisciplinary areas bridging biotechnology and biomedical sciences. The ability to isolate and maintain pluripotent stem cells in culture offers exciting possibilities for replacing damaged or diseased organs and tissues. Moreover, stem cells will provide opportunities for major advances in our understanding of fundamental developmental processes.

The study of pluripotent stem cells derived from early embryos or fetal tissues has shown that they are capable of replicating indefinitely in vitro and possess the ability to differentiate into many cell types. Biotechnological advances under which growth conditions and factors can be identified and characterized are needed to guide such cells to form organ-specific tissues.

Biomedical researchers are also investigating approaches to isolate and manipulate adult-derived multipotential stem cells that appear to possess considerably broader differentiation capacity than originally imagined.

Novel therapeutic strategies are being developed to take advantage of the ability of stem cells to proliferate in culture and to survive after transplantation into various tissues, where they may integrate and stably express foreign genes, or repopulate damaged or diseased organs such as the heart, brain, or pancreas.

These presentations foster a broader understanding of the factors that regulate the biology and plasticity of stem cells through the picture they provide of the "state of the science" of stem cell biology and by framing the many questions that remain to be answered.

NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.

ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Read More Show Less

Product Details

  • ISBN-13: 9781573315340
  • Publisher: Wiley
  • Publication date: 5/23/2005
  • Series: Annals of the New York Academy of Sciences Series , #1049
  • Edition description: Volume 1049, May 2005
  • Edition number: 1
  • Pages: 216
  • Product dimensions: 6.10 (w) x 9.00 (h) x 0.46 (d)

Table of Contents

Preface: Jitka Ourednik, Václav Ourednik, Donald Sakaguchi, and Marit Nilsen-Hamilton.

Part I: Regional Determinants of Cell Fate:.

1. Oxygen in the Cultivation of Stem Cells. By Marie Csete.

2. DNA Damage-Induced Programmed Cell Death: Potential Roles in Germ Cell Development. By Yukiko Yamada and Clark R. Coffman.

.

Part II: Intrinsic Determinants of Stem Cells:.

3. G Protein-Coupled Receptor Roles in Cell Migration and Cell Death Decisions: Angela R. Kamps and Clark R. Coffman.

4. Growth and Differentiation of Astrocytes and Neural Progenitor Cells on Micropatterned Polymer Films: Jennifer B. Recknor, D S. Sakaguchi, and S K. Mallapragada.

5. Cellular and Molecular Regulation of Hematopoietic and Intestinal Stem Cell Behavior: Xi C. He, Jiwang Zhang, and Linheng Li.

6. The Function of the Neuronal Proteins Shc and Huntingtin in Stem Cells and Neurons: Pharmacologic Exploitation for Human Brain Diseases: Chiara Zuccato, Luciano Conti, Erika Reitano, Marzia Tartari, and Elena Cattaneo.

7. Engineering a Dopaminergic Phenotype in Stem/Precursor Cells: Role of Nurr1, Glia-Derived Signals, and Wnts: Ernest Arenas.

.

Part III: Transdifferentiation:.

8. Umbilical Cord Blood-Derived Stem Cells and Brain Repair: Paul R. Sanberg, Alison E. Willing, Svitlana Garbuzova-Davis, Samuel Saporta, Guoqing Liu, Cyndy Davis Sanberg, Paula C. Bickford, Stephen K. Klasko, and Nagwa S. El-Badri.

9. Infusion of Human Umbilical Cord Blood Ameliorates Neurologic Deficits in Rats with Hemorrhagic Brain Injury: Zhenhong Nan, andrew Grande, Cyndy D. Sanberg, Paul R. Sanberg, and Walter C. Low.

10. How Wnt Signaling Affects Bone Repair by Mesenchymal Stem Cells from the Bone Marrow: Carl A. Gregory, William G. Gunn, Emigdio Reyes, Angela J. Smolarz, James Munoz, Jeffrey L. Spees, and Darwin J. Prockop.

.

Part IV: Stem Cell Responses to Perturbation:.

11. Human Retinal Progenitor Cells Grown as Neurospheres Demonstrate Time-Dependent Changes in Neuronal and Glial Cell Fate Potential: David M. Gamm, Aaron D. Nelson, and Clive N. Svendsen.

12. Neural Progenitor Cell Transplants into the Developing and Mature Central Nervous System: D S. Sakaguchi, S J. Van Hoffelen, S D. Grozdanic, Y H. Kwon, R H. Kardon, and M J. Young.

13. Stem Cells for Retinal Degenerative Disorders: Jason S. Meyer, Martin L. Katz, and Mark D. Kirk.

14. Magnetic Resonance Tracking of Implanted Adult and Embryonic Stem Cells in Injured Brain and Spinal Cord: Eva Syková and Pavla Jendelová.

15. The Miniature Pig as an Animal Model in Biomedical Research: Petr Vodicka, Karel Smetana, Jr., Barbora Dvoránková, Teresa Emerick, Yingzhi Z. Xu, Jitka Ourednik, Václav Ourednik, and Jan Motlík.

.

Part V: Reciprocal Communication between Graft and Host:.

16. Graft/Host Relationships in the Developing and Regenerating CNS of Mammals: Václav Ourednik and Jitka Ourednik.

17. Grafted Neural Stem Cells Shield the Host Environment from Oxidative Stress: Lalitha Madhavan, Václav Ourednik, and Jitka Ourednik.

18. Administration of Allogenic Stem Cells Dosed to Secure Cardiogenesis and Sustained Infarct Repair: Atta Behfar, Denice M. Hodgson, Leonid V. Zingman, Carmen Perez-Terzic, Satsuki Yamada, Garvan C. Kane, Alexey E. Alekseev, Michel Pucéat, and andre Terzic.

Index of Contributors

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)