Stereotactic Body Radiation Therapy

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Overview

This text provides oncology professionals with a practical understanding of the basic science, technical aspects, and clinical indications of stereotactic body radiation therapy, including radiosurgery, radiotherapy, and radioablation. Coverage includes discussions of relevant classical and molecular radiobiological principles, critical evaluations of currently used techniques, and background clinical oncology information plus summaries of reported outcomes for patients treated in the lung, liver, and spine.

This text provides oncology professionals with a practical understanding of the basic science, technical aspects, and clinical indications of stereotactic body radiation therapy, including radiosurgery, radiotherapy, and radioablation. Coverage includes discussions of relevant classical and molecular radiobiological principles, critical evaluations of currently used techniques, and background clinical oncology information plus summaries of reported outcomes for patients treated in the lung, liver, and spine.

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Editorial Reviews

From The Critics
Reviewer: James G Douglas, MD, MS (Memorial Hospital of Sweetwater County)
Description: This book describes the latest technological advance in delivery of radiotherapy — stereotactic body radiotherapy. It adequately covers the radiobiological and physics principles behind such technologies and then describes the early experience in different disease sites.
Purpose: The authors state that the book is "intended to be a primer for radiation oncologists, radiobiologists, dosimetrists, therapists, and other invaluable members of the team who wish to become comfortable with emerging techniques that raise radiotherapy to bold new heights." Stereotactic body radiation therapy (SBRT) is an emerging technique and a book such as this is needed. The authors do meet their goal to introduce the principles and techniques of SBRT. Whether this emerging technology will raise radiotherapy to "bold new heights" remains to be proven.
Audience: The audience includes those radiation oncologists, physicists, radiation oncology residents, and radiobiologists who are interested in pursuing this technology. The authors are the pioneers in this field.
Features: The book is divided into three main sections: radiobiological principles; physics and dosimetry concepts; and clinical applications of the technique. Both the radiobiological basis of the procedure and the dosimetric and physics components are very well covered. The problems with normal tissue constraints and target delineation, immobilization, and dose imhomogeneity are eloquently discussed. As this technique is relatively new, the clinical section is brief but does update the reader on the current "state of affairs."
Assessment: This is a very well written book on an emerging technology in radiation oncology. It is well organized and provides valuable information to anyone considering the use of SBRT. It will be a useful primer for those interested in pursuing SBRT.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780781754200
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 9/27/2004
  • Pages: 160
  • Product dimensions: 8.60 (w) x 11.20 (h) x 0.50 (d)

Table of Contents

Prologue : the clinical transition from intracranial to extracranial stereotactic radiation therapy 1
Sect. I The radiobiology of stereotactic body radiation therapy (SBRT) 7
1 Estimation of required doses in stereotactic body radiation therapy 7
2 The cellular signaling response to radiation 15
3 Radiation effects and the role of cytokines : mechanisms and potential clinical implications 19
4 Normal tissue dose constraints applied in lung stereotactic body radiation therapy 29
5 Normal tissue dose constraints in stereotactic body radiation therapy for liver tumors 39
6 Special problems in stereotactic body radiation therapy : dose rate effect, dose inhomogeneity, and target margin selection 47
Sect. II The physics and dosimetry of stereotactic body radiation therapy 51
7 Immobilization, localization, and repositioning methods in stereotactic body radiation therapy 51
8 Dosimetry of stereotactic body radiation therapy 57
9 Quality assurance in stereotactic body radiation therapy 69
Sect. III Initiating and building a clinical stereotactic body radiation therapy program 79
10 Clinical operational issues : optimizing the treatment process 79
11 Commissioning and accreditation of a stereotactic body radiation therapy program 85
12 Personnel training for stereotactic body radiation therapy 95
13 Stereotactic body radiation therapy for lung tumors 99
Case studies in lung SBRT : application of the FOCAL unit 108
Case study in lung SBRT : the Indiana University phase II protocol for medically inoperable lung cancer 110
Case study in lung SBRT : long-term follow-up in a patient with a history of tuberculosis
14 Stereotactic body radiation therapy for liver tumors 115
Case study in liver SBRT : dose optimization via inverse treatment planning 125
15 Stereotactic body radiation therapy for renal cell carcinoma 129
16 Stereotactic body radiation therapy for retroperitoneal and pelvic tumors 135
Case study in prostate SBRT : the SHARP protocol 140
17 Stereotactic body radiation therapy for paraspinal tumors 143
Case study of spinal SBRT : radiosurgery for vertebral metastasis 150
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