Strategies and Tactics in Organic Synthesis

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Overview

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project.
In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.

- Personal accounts of research in organic chemistry.
- Written by internationally renowned scientists.
- Details state of the art organic synthesis.

Audience: Organic chemists; libraries at all colleges and universities and chemical and pharmaceutical companies.

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Editorial Reviews

From the Publisher
"This book is a chronicle of synthetic problems and strategies written by leading organic chemists, who give their own personal accounts of the practice of organic synthesis. It is part lab. notes and memoir and should be an interesting read for both organic chemistry students and practitioners alike."
J. AM. CHEM. SOC, Vol. 128, no. 10, 2006
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Product Details

Table of Contents

1. A Remarkable Architectural Self-Construction Process is Discovered in a Synthesis of FR182877.

2. Total Synthesis of the DNA Azinomycin Family of Antitumor Agents.

3. Breaking the Symmetry of Silacyclic Templates to Assemble Pinolidoxin and Herbarumin I.

4. Quinone Sesquiterpenes: A Challenge For The Development Of A New Synthetic Methodology.

5. Strategies Leading to the Synthesis of a Novel Ketolide Antibiotic.

6. Towards the Syntheses of Natural Protoilludanes and Linear Triquinanes from Cycloundecadienynes.

7. Development of General Synthetic Strategies Towards Oligocycloalkanes.
8. Achmatowicz Approach to 5,6-Dihydro-2H-pyran-2-one Containing Natural Products.

9. First Total Synthesis of (+)-Amphidinolide T1.

10. Total Synthesis of Zincophorin and its Methyl Ester.

11. The Enantioselective Synthesis of Morphine.

12. The Invention of the Alkynol Cycloisomerization Reaction: Application to the Synthesis of Digitoxin.

13. Biomimetic Synthesis of Natural Products Isolated from Bignoniaceae.

14. Stereoselective Synthesis of Polyunsaturated A-Alkylidenebutenolides: The Total Synthesis of the Xerulins.

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