Strategies and Tactics in Organic Synthesis

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A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.

• Presents state-of-the-art developments in organic synthesis
• Provides insight and offers new perspective to problem-solving
• Written by leading experts in the field

Audience: Organic chemists; libraries at all colleges and universities and chemical and pharmaceutical companies.

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Editorial Reviews

From the Publisher
"This book is a chronicle of synthetic problems and strategies written by leading organic chemists, who give their own personal accounts of the practice of organic synthesis. It is part lab. notes and memoir and should be an interesting read for both organic chemistry students and practitioners alike."
J. AM. CHEM. SOC, Vol. 128, no. 10, 2006
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Product Details

Table of Contents

1 The total synthesis of luzopeptins 1
2 Synthesis of geldanamycin using glycolate aldol reactions 38
3 From methylene bridged glycoluril dimers to cucurbit[n]uril analogs with some detours along the way 71
4 Application of silicon-assisted intramolecular cross-coupling in total synthesis of (+)-brasilenyne 100
5 Samarium(II) promoted ketyl olefin cyclizations applied to the total syntheses of(-)-steganone and (+)-isoschizandrin 137
6 The synthesis of polycavernoside A. : an example of conformationally guided macrolactonization 173
7 First total synthesis of several natural products based on alkyne-Co[subscript 2](CO)[subscript 6] complexes 211
8 Total synthesis of myriaporones 1, 3, and 4 246
9 Adventures in natural product synthesis : from deep sea sponge to pilot plant : the large scale total synthesis of the marine natural product (+)-discodermolide 269
10 Synthesis of aprepitant 321
11 Total synthesis and mechanism of action studies on the antitumor alkaloid, (-)-agelastatin A 352
12 Design and synthesis of cooperative "pinwheel" fluorescent sensors 395
13 Functionalization of pyridines and thiazoles via the halogen-dance reaction, application to the total synthesis of caerulomycin C and WS75624 B 415
14 Diastereoselective intramolecular 4+3 cycloaddition and an enantioselective total synthesis of (+)-dactylol 437
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