Strategies for Organic Drug Synthesis and Design / Edition 1

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The field of organic synthesis has influenced chemistry and in turn society in a profound number of areas, from the development of medicinal agents to an astonishing variety of polymers. This book focuses upon the strategies and organic transformations which have been used to prepare the various structural classes that have been investigated as drugs. Special attention is paid to clarifying individual reactions of the drugs, and the text includes an extensive "Reaction Index."

Incl.carbocyclic & heterocyclic compounds, routes used to prepare 600+ compounds, chemical reactions of 3000+ entries.

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Editorial Reviews

Presents a selection of syntheses from the five-volume series , chosen to illustrate the strategy and organic transformation used to prepare various structural classes investigated as drugs. Focus is on agents that have been granted nonproprietary names, and drugs have been selected mainly for illustrative value of the chemistry used for synthesis. Discusses biological rationales for drug classes and actions of individual agents, and offers capsule presentations of basic principles of drug action. Includes reaction flow charts detailing routes used to prepare some 600 compounds, plus a reaction index. For those working in organic, medicinal, and pharmaceutical chemistry. Annotation c. by Book News, Inc., Portland, Or.
From the Publisher
?In this book, Lednicer presents a detailed discussion of strategies toward the synthesis of pharmaceutical compounds. . . The strength of the book is the wealth of data collected in one relatively short tone?.
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Product Details

  • ISBN-13: 9780471196570
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 1/28/1998
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 520
  • Product dimensions: 6.38 (w) x 9.43 (h) x 1.09 (d)

Meet the Author

Daniel Lednicer has devoted his career in both the private and public sectors to the search for new therapeutic agents. A former chemist and project officer at the National Cancer Institute, he has held the positions of director of chemical research at Mead Johnson, director of pharmaceutical sciences at Adria Laboratories, and pharmaceutical manager at Analytical Biochemistry Laboratories. He is the editor of the Wiley series The Organic Chemistry of Drug Synthesis."
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Table of Contents

1 Prostaglandins, Protease Inhibitors, and Retinoids 1
2 Drugs Based on a Substituted Benzene Ring 30
3 Indenes, Naphthalenes, and Other Polycyclic Aromatic Compounds 63
4 Steroids Part 1: Estranes, Gonanes, and Androstanes 84
5 Steroids Part 2: Compounds Related to Progesterone and Cortisone 121
6 Nonsteroidal Estrogens and their Antagonists 146
7 Opioid Analgesics 161
8 Drugs Based on Five-Membered Heterocycles 185
9 Drugs Based on Six-Membered Heterocycles 242
10 Five-Membered Heterocycles Fused to a Benzene Ring 286
11 Six-Membered Heterocycles Fused to a Benzene Ring 311
12 Seven-Membered Heterocyclic Rings Fused to Benzene 362
13 Heterocycles Fused to Two Benzene Rings 379
14 Beta-Lactam Antibiotics 401
15 Heterocycles Fused to Other Heterocyclic Rings 431
Cross Index of Compounds 469
Reaction Index 477
Subject Index 493
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