Stress, the Aging Brain, and the Mechanisms of Neuron Death

Stress, the Aging Brain, and the Mechanisms of Neuron Death

by Robert M. Sapolsky
     
 

Honorable Mention in the category of Biological Sciences, 1992 Professional/Scholarly Publishing Annual Awards Competition presented by the Association of American Publishers, Inc.

Looking beyond the now widely recognized relationships between stress and physical illness, this accessible and engagingly written book suggests that stress and stress-related

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Overview

Honorable Mention in the category of Biological Sciences, 1992 Professional/Scholarly Publishing Annual Awards Competition presented by the Association of American Publishers, Inc.

Looking beyond the now widely recognized relationships between stress and physical illness, this accessible and engagingly written book suggests that stress and stress-related hormones can also endanger the brain. Strategies to reduce stress and methods to protect neurons from further damage are proposed, and the relevance for humans of the animal research findings are clearly delineated.

Sapolsky provides an extensive review of the recent, exciting data on glucocorticoids, the adrenal steroid hormones (hydrocortisone or cortisol in humans) that are released during stress. Excessive exposure to these hormones can damage the brain and make neurons more vulnerable to neurological insults. The findings he reports and ideas he synthesizes may have profound implications for understanding brain aging and resistance of the brain to the damaging effects of strokes, seizures, and possibly Alzheimer's disease.

In part I Sapolsky focuses on how the failure of glucocorticoid regulation and subsequent excessive secretion combine to cause a complex cascade of degeneration in the brain during aging. In part 11 he addresses the implications of glucocorticoid neurotoxicity for neurology. Each chapter includes a helpful summary of the major points discussed as well as a capsule review of information from the previous chapters.

Robert M. Sapolsky is Associate Professor of Biology and Neuroscience at Stanford University. He is also Research Associate at the Institute for Primate Research, National Museums of Kenya, Nairobi, and a MacArthur Fellow.

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Product Details

ISBN-13:
9780262193207
Publisher:
MIT Press
Publication date:
09/23/1992
Series:
Bradford Books Series
Pages:
441
Product dimensions:
7.41(w) x 10.33(h) x 1.43(d)

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Table of Contents

Preface and Acknowledgments
Pt. IThe Glucocorticoid Cascade Hypothesis1
1The Stress-Response and the Emergence of Stress-Related Disease3
2An Introduction to the Adrenocortical Axis11
3Glucocorticoid Concentrations in the Aged Rat: A Problem of Hypersecretion29
4The Problem of Receptor Loss51
5The Hippocampus as a Mediator of Glucocorticoid Feedback Regulation71
6Glucocorticoid Neurotoxicity95
Pt. IIHow Does a Neuron Die?117
7Glucocorticoids Endanger Hippocampal Neurons119
8A Brief Interlude: Programmed Cell Death145
9Metabolic Chaos I: The Mediators of Necrotic Neuronal Injury159
10Metabolic Chaos Il: The Role of Energy Failure in Necrotic Neuronal Injury201
11How Do Glucocorticoids Endanger the Hippocampal Neuron?223
Pt. IIIHow Depressing Is All of This?259
12Individual Differences and Adrenocortical Function: Why Do Some Individuals Secrete More Glucocorticoids Than Others?261
13Interventions at the Time of Neurological Insults299
14Is This Relevant to the Human?305
References341
Index425

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