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Structural Biology of DNA Damage and Repair

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The human genome is continuously exposed to many classes of genotoxins. Of these, three that will be discussed herein include 5,6-dihydroxy-5,6- dihydrothymine (thymine glycol; Tg), O6-methylguanine (O6MeG), and benzo[a]pyrene. In all cases, if the genome is not repaired, these and other genotoxic lesions precipitate serious biological consequences, including altered gene expression, mutation, and cell death. In addition to the genotoxic responses, it is increasingly being recognized that DNA lesions can alter the epigenetic profiles that are imprinted by naturally occurring DNA modifications.

The impetus for this volume came from a recent symposium sponsored by the ACS Division of Chemical Toxicology, bringing together scientists interested in the synthesis and structures of site-specific DNA adducts and in mechanistic aspects of DNA repair. This volume presents work at the interface between the structural biology of DNA damage and DNA repair.

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Product Details

  • ISBN-13: 9780841225749
  • Publisher: American Chemical Society
  • Publication date: 3/21/2011
  • Series: ACS Symposium Series , #1041
  • Pages: 138
  • Product dimensions: 5.90 (w) x 9.00 (h) x 0.50 (d)

Meet the Author

Michael P. Stone is Professor & Department Chairman of the Department of Chemistry at Vanderbuilt University.

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Table of Contents


1. Overview
Michael P. Stone
2. Structural Consequences of Epimerization of Thymine Glycol Lesions in Duplex DNA: Implications for DNA Repair
Kyle L. Brown, Marina Roginskaya, Yue Zou, Alvin Altamirano, Ashis K. Basu, and Michael P. Stone
3. Structural Studies of Alkylpurine DNA Glycosylases
Emily H. Rubinson, Suraj Adhikary, and Brandt F. Eichman
4. Dynamics in Uracil Base Excision Repair
Joshua I. Friedman and James T. Stivers
5. Biochemical and Structural Domain Analysis of Xeroderma Pigmentosum Complementation Group C Protein
Steven M. Shell and Walter J. Chazin
6. Effects of Sequence Context on O6-Alkylguanine DNA Alkyltransferase Repair of O6-Alkyl-Deoxyguanosine Adducts
Rebecca Guza, Anthony E. Pegg, and Natalia Tretyakova
7. Impact of Carcinogen-DNA Adducts on DNA Methylation
Elizaveta S. Gromova, Oksana M. Subach, Vladimir B. Baskunov, and Nicholas E. Geacintov

Indexes Author Index Subject Index

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