Structure and Function of Intrinsically Disordered Proteins

by Peter Tompa, Alan Fersht

Overview

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug dev

Product Details

ISBN-13:	9781040179352
Publisher:	CRC Press
Publication date:	11/18/2009
Sold by:	Barnes & Noble
Format:	eBook
Pages:	359
File size:	8 MB

About the Author

Peter Tompa is Group Leader in the Laboratory of Intrinsically Disordered Proteins, Institute of Enzymology, Biological Research Center at the Hungarian Academy of Sciences in Budapest.

Table of Contents

Principles of Protein Structure and Function. A Brief History of Protein Disorder. Indirect Techniques for Recognizing and Characterizing Protein Disorder. Hydrodynamic Techniques. Spectroscopic Techniques for Characterizing Disorder. Nuclear Magnetic Resonance. Proteomic Approaches for the Identification of IDPs. IDPs under Conditions Approaching In Vivo. Prediction of Disorder. Structure of IDPs. Biological Processes Enriched in Disorder. Molecular Functions of Disordered Proteins. Evolution and Prevalence of Disorder. Extension of the Structure-Function Paradigm. Structural Disorder and Disease. References.

Editorial Reviews

"Tompa's masterly compendium on intrinsically disordered proteins arrives at just the right time to fill a conspicuous void on this important topic. His eminently readable book is broad enough to educate beginners but deep enough to inform experts."
—George Rose, Ph.D., Johns Hopkins University, Baltimore, Maryland, USA

"Peter Tompa’s fine comprehensive overview of this rapidly advancing field is of timely importance, both for its documentation and for emphasizing the importance of IDPs in biology and protein science. … This book demonstrates Tompa’s considerable command of the field, providing appropriate examples and ample details in every respect. Its coverage of the latest developments in the field is impressive, and the author manages to strike a good balance between detail and concept to lead the reader through this novel field."
—From the Foreword by Professor Sir Alan Fersht, University of Cambridge, UK

"The book is just superb—a thorough, comprehensive and lucid discussion of intrinsically disordered proteins."
—Joel L. Sussman, Weizmann Institute of Science, Rehovot, Israel

From the Publisher