Structure-based Drug Discovery

by Harren Jhoti (Editor), Andrew R. Leach (Editor)

Overview

Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book.

The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.

Product Details

ISBN-13:	9781402044069
Publisher:	Springer Netherlands
Publication date:	02/21/2007
Edition description:	2007
Pages:	250
Product dimensions:	6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

Five Years of Increasing Structural Biology Throughput - A Retrospective Analysis.- Protein Production for Structural Genomics - Strategies for the Next Phase.- to Fragment Screening.- Fragment-Based NMR Screening in Lead Discovery.- Fragment-Based Screening by X-ray Crystallography.- Scaffold-Based Drug Discovery.- Biophysical Methods.- Illustration of Current Challenges in Molecular Docking.- Scoring Functions.

Editorial Reviews

From the reviews:

"Structure-based drug design (SBDD) is now an integral component of the drug discovery process. … The book’s core subject matter of fragment-based screening is an exciting and important development in drug discovery. These chapters are generally the strongest in the book and make it a good reference volume … ." (Robert Powers, Journal of the American Chemical Society, Vol. 129 (32), 2007)

From the Publisher