Structure-based Drug Discovery / Edition 1

Structure-based Drug Discovery / Edition 1

by Harren Jhoti
     
 

ISBN-10: 1402044062

ISBN-13: 9781402044069

Pub. Date: 02/21/2007

Publisher: Springer Netherlands

Discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based

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Overview

Discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book. The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.

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Product Details

ISBN-13:
9781402044069
Publisher:
Springer Netherlands
Publication date:
02/21/2007
Edition description:
2007
Pages:
250
Product dimensions:
6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

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1.
Five Years of Increasing Structural Biology Throughput – A Retrospective Analysis,
Enrique Abola, Dennis D. Carlton,
Peter Kuhn, and Raymond C. Stevens

·
Introduction

• Structural Biology and Genomics

• Protein Structure Initiative

·
New Technologies in PSI-1 pipelines

• High-throughput Structural Determination pipeline

o

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