Structure-based Drug Discovery / Edition 1

by Harren Jhoti, Andrew R. Leach

Overview

This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.

Product Details

ISBN-13:	9789048171231
Publisher:	Springer Netherlands
Publication date:	11/19/2010
Edition description:	Softcover reprint of hardcover 1st ed. 2007
Pages:	250
Product dimensions:	6.10(w) x 9.25(h) x 0.24(d)

Table of Contents

Five Years of Increasing Structural Biology Throughput - A Retrospective Analysis.- Protein Production for Structural Genomics - Strategies for the Next Phase.- to Fragment Screening.- Fragment-Based NMR Screening in Lead Discovery.- Fragment-Based Screening by X-ray Crystallography.- Scaffold-Based Drug Discovery.- Biophysical Methods.- Illustration of Current Challenges in Molecular Docking.- Scoring Functions.

Editorial Reviews

From the reviews:

"Structure-based drug design (SBDD) is now an integral component of the drug discovery process. … The book’s core subject matter of fragment-based screening is an exciting and important development in drug discovery. These chapters are generally the strongest in the book and make it a good reference volume … ." (Robert Powers, Journal of the American Chemical Society, Vol. 129 (32), 2007)

From the Publisher