Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels / Edition 1

Hardcover (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $85.00
Usually ships in 1-2 business days
(Save 50%)
Other sellers (Hardcover)
  • All (7) from $85.00   
  • New (6) from $85.00   
  • Used (1) from $163.19   


This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.

Read More Show Less

Editorial Reviews

From the Publisher
“This volume provides a very straightforward overview of complex pharmaceutical industry processes and will certainly be beneficial to readers with diverse backgrounds; particularly for those who are not specialists in protein manufacturing, but have a need to understand the entire manufacturing and commercialization process.” (The Quarterly Review of Biology, June 2010)
Read More Show Less

Product Details

  • ISBN-13: 9780471930136
  • Publisher: Wiley
  • Publication date: 2/9/2009
  • Edition number: 1
  • Pages: 483
  • Product dimensions: 6.30 (w) x 9.30 (h) x 1.10 (d)

Meet the Author

VALENTIN K. GRIBKOFF, PHD, is the Chief Scientific Officer and Senior Vice President of Discovery Research at Knopp Neurosciences. He is also an Adjunct Associate Professor in the Department of Pharmacology at Yale University School of Medicine. Dr. Gribkoff has published 100 articles and holds twelve patents.

LEONARD K. KACZMAREK, PHD, is a Professor in the Departments of Pharmacology and Molecular and Cellular Physiology at Yale University School of Medicine. Dr. Kaczmarek has edited or authored two books and over 200 articles. He has served on the editorial boards of The Journal of Neuroscience, Journal of Molecular Neuroscience, The Journal of Experimental Biology, and New Biologist.

Read More Show Less

Table of Contents




1 Neuronal L-Type Voltage-Gated Calcium Channels (Alexander Scriabine and David J. Triggle).

2 Voltage-Gated N-Type and T-Type Calcium Channels and Excitability Disorders (Elizabeth Tringham and Terrance P. Snutch).

3 Voltage-Gated Sodium Channels: Multiple Roles in the Pathophysiology of Pain (Sulayman D. Dib-Hajj, Bryan C. Hains, Joel A. Black, and Stephen G. Waxman).

4 The Role of Ion Channels in the Etiology and Development of Gliomas (Amy K. Weaver and Harald Sontheimer).

5 Shaker Family Kv1 Voltage-Gated Potassium Channels in Mammalian Brain Neurons (Helene Vacher and James S. Trimmer).

6 Unique Mitochondrial Ion Channels: Roles in Synaptic Transmission and Programmed Cell Death (Elizabeth A. Jonas).

7 Regulation of Neuronal Excitability by the Sodium-Activated Potassium Channels Slick (SLO2.1) and Slack (SLO2.2) (Valentin K. Gribkoff and Leonard K. Kaczmarek).


8 Alternative Splicing of Neuronal Cav2 Calcium Channels (Diane Lipscombe, Summer E. Allen, Annette C. Gray, Spiro Marangoudakis, and Jesica Raingo).

9 Effect of Hypoxia/Ischemia on Voltage-Dependent Channels (Xiang Q. Gu, Hang Yao, and Gabriel G. Haddad).

10 In Vivo Roles of Ion Channel Regulatory Protein Complexes in Neuronal Physiology and Behavior (Smitha Reddy, Mohammad Shahidullah, and Irwin B. Levitan).

11 Regulation of Neuronal Ion Channels by G-Protein-Coupled Receptors in Sympathetic Neurons (Mark S. Shapiro and Nikita Gamper).

12 BK Channels: Regulation of Expression and Physiological Impact (P. Kundu, A. Alioua, Y. Kumar, R. Lu, J. Ou, E. Sanchez-Pastor, M. Li, E. Stefani, and L. Toro).

13 Structural Basis for Auxiliary KChIP Modulation of Kv4 Channels (KeWei Wang and Jijie Chai).


14 Sodium Channel Blockers for the Treatment of Chronic Pain (Mark R. Bowlby and Edward Kaftan).

15 Neuronal Kv7 Potassium Channels as Emerging Targets for the Treatment of Pain (Steven I. Dworetzky and Valentin K. Gribkoff).

16 Small-Molecule Modulators of Large-Conductance, Calcium-Activated (BK) Channels (John E. Starrett Jr.).

17 High-Throughput Screening Technologies in Ion Channel Drug Discovery (Edward B. Stevens, Andrew D. Whyment, and J. Mark Treherne).


Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)