Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion: Proceedings of the Second International Conferences on "Structure and Function of Molecules Involved in Leukocyte Adhesion II" Held in Titisee, Germany, October 2-6, 1991 / Edition 1

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Leukocyte adhesion molecules have been the subject of intense basic and preclinical research. Results from clinical trials obtained sofar with antibodies directed towards these surface proteins offer promise for the prevention of graft rejection and effective treatment of acute and chronic inflammatory disease. This volume presents a comprehensive review of contemporary research on the structure, function and regulation of leukocyte adhesion molecules and their ligands, from the molecular to the clinical level. The blend of basic science and clinical applications presented in Structure, Function and Regulation of Molecules Involved in Leukocyte Adhesion provides clear evidence of the biological importance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion. It will appeal to a broad range of readers in immunology and cell biology.
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Product Details

  • ISBN-13: 9780387978703
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 1/28/1993
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 396

Table of Contents

Pt. 1 Structure and Function of the Integrins
1 Leukocyte Integrin Activation 3
2 Activation of LFA-1: Role of Cations 14
3 An Antibody that Promotes Adhesion Events Mediated by Both LFA-1 and CR3 25
4 Function of a Soluble Human [beta]2 Integrin CD11b/CD18 34
5 Mac-1 (CD11b/CD18) and Adherence-Dependent Neutrophil Locomotion 45
6 Functional Comparison of the Integrins [alpha(superscript 4)][beta(subscript 1)] (VLA-4) and [alpha(superscript 4)][beta(subscript 7)] 58
7 Functional Mapping and Regulation of VLA-4 Adhesion Activities 67
8 Signal Transduction Through a Novel Phagocyte Integrin 78
9 Interactions of the Plasmodium falciparum-Infected Erythrocyte With ICAM-1 92
Pt. 2 Structure and Function of the Selections
10 The Selectins 107
11 Leukocyte Interactions Mediated by P-Selectin 135
12 PMN Extravasation in Acute Inflammation: A Role for Selectin Interaction in Initial PMN-Endothelial Cell Recognition 151
13 Interaction of LAM-1 With an Inducible Ligand Supports Leukocyte Adhesion to Endothelium 168
14 The Contribution of L-Selectin to Leukocyte Trafficking In Vivo 182
15 L-Selectin as a Mediator of Leukocyte Binding to Myelinated Tracts of the Central Nervous System: Possible Pathophysiologic Significance 191
16 Selectin-Dependent Monocyte Adhesion in Frozen Sections of Rheumatoid Synovitis 200
Pt. 3 Cell Biology of Adhesion Molecules
17 Fc Receptor Function and Cytoplasmic Domain Heterogeneity 217
18 Regulation of Antigen-Independent Adhesion of CD4 T Cells
19 The Adhesion and Transendothelial Migration of Human T Lymphocytes 232
20 Changes in Topography of Cell Adhesion Molecules During Lymphocyte Migration Across Endothelium 242
21 Cytokines and the Control of Endothelial Cell Adhesiveness for Leukocytes in Inflammation 251
22 Co-stimulation of T-Lymphocyte Activation by Adhesion Molecules 256
Pt. 4 In Vivo Models
23 The Role of CD11a/CD18-CD54 Interactions in the Evolution of Animal Models of Tissue Injury 273
24 Mechanisms and Consequences of Leukocyte Adhesion 279
25 The Role of Cellular Adhesion Molecules in Acute and Chronic Airway Inflammation 291
26 Adhesion Molecules in the Shwartzman Response 306
27 Clinical and Immunological Features Associated With Bovine Leukocyte Adhesion Deficiency 314
28 The Role of Leukocyte Adhesion Molecules During Ischemia and Reperfusion 328
Pt. 5 Clinical
29 Abnormalities of LECAM-1- and MAC-1-Dependent Neutrophil-Endothelial Cell Adhesion in the Developing Host 337
30 Expression of ICAM-1 in Human Liver 356
31 Detection and Characterization of Circulating ICAM-1 367
32 Phase I Clinical Trial of Anti-ICAM-1 (CD54) Monoclonal Antibody Immunosuppression in Renal Allograft Recipients
33 Adhesion Molecules in Human Renal Allograft Rejection: Immunohistochemical Analysis of ICAM-1, ICAM-2, ICAM-3, VCAM-1, and ELAM-1 380
Index 389
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