Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion

Overview

Leukocyte adhesion molecules have been the subject of intense basic and preclinical research. Results from clinical trials obtained sofar with antibodies directed towards these surface proteins offer promise for the prevention of graft rejection and effective treatment of acute and chronic inflammatory disease. This volume presents a comprehensive review of contemporary research on the structure, function and regulation of leukocyte adhesion molecules and their ligands, from the molecular to the clinical level. ...
See more details below
Paperback (Softcover reprint of the original 1st ed. 1993)
$99.00
BN.com price
Other sellers (Paperback)
  • All (8) from $91.20   
  • New (7) from $91.20   
  • Used (1) from $148.56   
Sending request ...

Overview

Leukocyte adhesion molecules have been the subject of intense basic and preclinical research. Results from clinical trials obtained sofar with antibodies directed towards these surface proteins offer promise for the prevention of graft rejection and effective treatment of acute and chronic inflammatory disease. This volume presents a comprehensive review of contemporary research on the structure, function and regulation of leukocyte adhesion molecules and their ligands, from the molecular to the clinical level. The blend of basic science and clinical applications presented in Structure, Function and Regulation of Molecules Involved in Leukocyte Adhesion provides clear evidence of the biological importance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion. It will appeal to a broad range of readers in immunology and cell biology.
Read More Show Less

Product Details

  • ISBN-13: 9781461392682
  • Publisher: Springer New York
  • Publication date: 7/31/2012
  • Edition description: Softcover reprint of the original 1st ed. 1993
  • Edition number: 1
  • Pages: 396
  • Product dimensions: 6.14 (w) x 9.21 (h) x 0.86 (d)

Table of Contents

1: Structure and Function of the Integrins.- 1. Leukocyte Integrin Activation.- 2. Activation of LFA-1: Role of Cations.- 3. An Antibody that Promotes Adhesion Events Mediated by Both LFA-1 and CR3.- 4. Function of a Soluble Human—2 Integrin CD11b/CD18.- 5. Mac-1 (CD11b/CD18) and Adherence-Dependent Neutrophil Locomotion.- 6. Functional Comparison of the Integrins—4?1 (VLA-4) and—4?7.- 7. Functional Mapping and Regulation of VLA-4 Adhesion Activities.- 8. Signal Transduction Through a Novel Phagocyte Integrin.- 9. Interactions of the Plasmodium falciparum-Infected Erythrocyte With ICAM-1.- 2: Structure and Function of the Selectins.- 10. The Selectins.- 11. Leukocyte Interactions Mediated by P-Selectin.- 12. PMN Extravasation in Acute Inflammation: A Role for Selectin Interaction in Initial PMN-Endothelial Cell Recognition.- 13. Interaction of LAM-1 With an Inducible Ligand Supports Leukocyte Adhesion to Endothelium.- 14. The Contribution of L-Selectin to Leukocyte Trafficking In Vivo.- 15. L-Selectin as a Mediator of Leukocyte Binding to Myelinated Tracts of the Central Nervous System: Possible Pathophysiologic Significance.- 16. Selectin-Dependent Monocyte Adhesion in Frozen Sections of Rheumatoid Synovitis.- 3: Cell Biology of Adhesion Molecules.- 17. Fc Receptor Function and Cytoplasmic Domain Heterogeneity.- 18. Regulation of Antigen-Independent Adhesion of CD4 T Cells.- 19. The Adhesion and Transendothelial Migration of Human T Lymphocytes.- 20. Changes in Topography of Cell Adhesion Molecules During Lymphocyte Migration Across Endothelium.- 21. Cytokines and the Control of Endothelial Cell Adhesiveness for Leukocytes in Inflammation.- 22. Co-stimulation of T-Lymphocyte Activation by Adhesion Molecules.- 4: In Vivo Models.- 23. The Role of CD11a/CD18–CD54 Interactions in the Evolution of Animal Models of Tissue Injury.- 24. Mechanisms and Consequences of Leukocyte Adhesion.- 25. The Role of Cellular Adhesion Molecules in Acute and Chronic Airway Inflammation.- 26. Adhesion Molecules in the Shwartzman Response.- 27. Clinical and Immunological Features Associated with Bovine Leukocyte Adhesion Deficiency.- 28. The Role of Leukocyte Adhesion Molecules During Ischemia and Reperfusion.- 5: Clinical.- 29. Abnormalities of LECAM-1- and MAC-1-Dependent Neutrophil-Endothelial Cell Adhesion in the Developing Host.- 30. Expression of ICAM-1 in Human Liver.- 31. Detection and Characterization of Circulating ICAM-1.- 32. Phase I Clinical Trial of Anti-ICAM-1 (CD54) Monoclonal Antibody Immunosuppression in Renal Allograft Recipients.- 33. Adhesion Molecules in Human Renal Allograft Rejection: Immunohishemical Analysis of ICAM-1, ICAM-2, ICAM-3, VCAM-1, and ELAM-1.
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)