Suicide Gene Therapy: Methods and Reviews / Edition 1 by Caroline J. Springer | 9781617372834 | Paperback | Barnes & Noble
Suicide Gene Therapy: Methods and Reviews / Edition 1

Suicide Gene Therapy: Methods and Reviews / Edition 1

by Caroline J. Springer
     
 

ISBN-10: 1617372838

ISBN-13: 9781617372834

Pub. Date: 11/09/2010

Publisher: Springer-Verlag New York, LLC

The first comprehensive review of both the theory and practice of suicide gene therapy. The authors cover all the major aspects of suicide gene therapy, including the design and use of vectors in gene transduction, various enzyme and prodrug systems, the mechanistic analysis of the bystander effect, the design and synthesis of prodrugs, immunological implications,

Overview

The first comprehensive review of both the theory and practice of suicide gene therapy. The authors cover all the major aspects of suicide gene therapy, including the design and use of vectors in gene transduction, various enzyme and prodrug systems, the mechanistic analysis of the bystander effect, the design and synthesis of prodrugs, immunological implications, and its clinical impact. They also describe all the cutting-edge methods needed to explore, study, and advance understanding of the basic biology underlying gene therapy. Each fully tested method includes step-by-step instructions, a discussion of the principle behind the technique, equipment and reagent lists, tips on troubleshooting and avoiding pitfalls, and notes on the interpretation and use of results.

Product Details

ISBN-13:
9781617372834
Publisher:
Springer-Verlag New York, LLC
Publication date:
11/09/2010
Series:
Methods in Molecular Medicine Series, #90
Edition description:
Softcover reprint of hardcover 1st ed. 2004
Pages:
555
Product dimensions:
5.98(w) x 9.02(h) x 0.35(d)

Related Subjects

Table of Contents

Introduction to the Background, Principles, and State of the Art in Suicide Gene Therapy
Ion Niculescu-Duvaz and Caroline J. Springer

Introduction to Vectors for Suicide Gene Therapy
Caroline J. Springer

Construction of VNP20009: A Novel, Genetically Stable Antibiotic-Sensitive Strain of Tumor-Targeting Salmonella for Parenteral Administration in Humans
Kenneth Brooks Low, Martina Ittensohn, Xiang Luo, Li-Mou Zheng, Ivan King, John M. Pawelek, and David Bermudes

Nonreplicating DNA Viral Vectors for Suicide Gene Therapy: The Adenoviral Vectors
Masato Yamamoto and David T. Curiel

Replication-Selective Oncolytic Adenoviruses
Gunnel Halldén, Stephen H. Thorne, Jingping Yang, and David H. Kirn

Retroviral Vectors for Suicide Gene Therapy
Colin Porter

Nonviral Liposomes
Andrew D. Miller

Peptide- and Polymer-Based Gene Delivery Vehicles
Richard Brokx and Jean Gariépy

Design of Prodrugs for Suicide Gene Therapy
Dan Niculescu-Duvaz, Ion Niculescu-Duvaz, and Caroline J. Springer

Cyhrome P450-Based Gene Therapies for Cancer
E. Antonio Chiocca and David J. Waxman

Tumor Sensitization to Purine Analogs by E. coli PNP
Kimberly V. Curlee, William B. Parker, and Eric J. Sorscher

Enzyme-Prodrug Systems: Carboxylesterase/CPT-11
Mary K. Danks and Philip M. Potter

Enzyme-Prodrug Systems: Thymidine Phosphorylase/5'-Deoxy-5-Fluorouridine
Alexandre Evrard, Joseph Ciccolini, Pierre Cuq, and Jean-Paul Cano

Methods to Improve Efficacy in Suicide Gene Therapy Approaches: Targeting Prodrug-Activating Enzymes Carboxypeptidase G2 and Nitroreductase to Different Subcellular Compartments
Silke Schepelmann, Robert Spooner, Frank Friedlos, and Richard Marais

Extracellular b-Glucuronidase for Gene-Directed Enzyme-Prodrug Therapy
Sabine Brüsselbach

Enhancementof Suicide Gene Prodrug Activation by Random Mutagenesis
Jean-Emmanuel Kurtz and Margaret E. Black

Combination Suicide Gene Therapy
Wolfgang Uckert, Brian Salmons, Christian Beltinger, Walter H. Günzburg, and Thomas Kammertöns

Immune Response to Suicide Gene Therapy
Shigeki Kuriyama, Hirohisa Tsujinoue, and Hitoshi Yoshiji

Targeting Cancer With Gene Therapy Using Hypoxia as a Stimulus
Gabi U. Dachs, Olga Greco, and Gillian M. Tozer

Radiation-Activated Antitumor Vectors
Simon D. Scott and Brian Marples

In Vitro and In Vivo Models for the Evaluation of GDEPT: Quantifying Bystander Killing in Cell Cultures and Tumors
William R. Wilson, Susan M. Pullen, Alison Hogg, Stephen M. Hobbs, Frederik B. Pruijn, and Kevin O. Hicks

Suicide Gene Therapy in Liver Tumors
Long R. Jiao, Roman Havlik, Joanna Nicholls, Steen Lindkaer Jensen, and Nagy A. Habib

Clinical Trials With GDEPT: Cytosine Deaminase and 5-Fluorocytosine
Nicola L. Brown and Nicholas R. Lemoine

The Nitroreductase/CB1954 Enzyme-Prodrug System
Nicola K. Green, David J. Kerr, Vivien Mautner, Peter A. Harris, and Peter F. Searle

Side Effects of Suicide Gene Therapy
Marjolijn M. van der Eb, Bertie de Leeuw, Alex J. van der Eb, and Rob C. Hoeben

Antibody-Directed Enzyme-Prodrug Therapy
R. Barbara Pedley, Surinder K. Sharma, Robert E. Hawkins, and Kerry A. Chester

Bioreductive Prodrugs for Cancer Therapy
Beatrice Seddon, Lloyd R. Kelland, and Paul Workman

Index

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