Supramolecular Structure and Function 7 / Edition 1

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This book is the proceedings of the 7th International Summer School on Biophysics: Supramolecular Structure and Function, held September 14-26, 2000, in Rovinj, Croatia.
An enormous amount of new knowledge on the molecular basis of biological phenomena has emerged in the rapidly expanding field of biophysics. The principles and methods of modern biophysics now provide a strong foundation for all of the biosciences, and serve as a rational common language for scientists from various disciplines.
The series of books on Supramolecular Structure and Function was inspired by the International Summer School on Biophysics, established under the sponsorship of IUPAB, UNESCO, and ICGEB, held in Rovinj, in 2001, and follows the successful interdisciplinary approach.
This volume covers some powerful methods, such as analytical centrifugation, mass spectrometry, fluorescence spectroscopy, infrared spectroscopy, electron spin resonance and nuclear magnetic resonance, for the study of complex biological structures, and discusses useful physical concepts as applied to biological and biochemical systems. Case-orientated studies concentrating on particular methodologies are presented and examples are given, addressing some of the most important aspects of structure-function relationship in biological assemblies. Biophysics nowadays collaborates closely with molecular biology and bioinformatics as well as with neurosciences, and this is also demonstrated in this book.
The book should be of interest both to experienced researchers wishing to widen their insight into molecular structure and function, and to younger scientists at the doctoral and postdoctoral level interested in the molecular nature of fundamental biological entities and phenomena.

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Product Details

  • ISBN-13: 9780306466724
  • Publisher: Springer US
  • Publication date: 9/6/2007
  • Edition description: 2001
  • Edition number: 1
  • Pages: 252
  • Product dimensions: 10.00 (w) x 7.00 (h) x 0.63 (d)

Table of Contents

1 Aspects of the Evolution of Biophysics: Polyelectrolytes and the Weizmann 1
2 Analytical Centrifugation: Looking at Aggregation in Free Solution 13
3 Mass Spectrometry of Peptides and Proteins - Principles and Features of Electrospray/Ionization-Mass Spectrometry (ESI-MS) and Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry (MALDI-MS) 27
4 Adsorption Kinetics of Low Density Lipoprotein onto a Hydrophobic-Hydrophilic Gradient Surface 45
5 Fluorescence Spectroscopic Studies on Structure and Function of Lipolytic Enzymes 63
6 Infrared Spectroscopy of Lipoproteins 75
7 New Approaches in Spin Labeling and Spin Trapping. Part One: ESR Studies of Local Chemical Environment 89
8 New Approaches in Spin Labeling and Spin Trapping. Part Two: NMR Detects Free Radicals 107
9 Free Radical Intermediates of Drugs and Xenobiotics 119
10 In vivo Detection of Nitric Oxide: Combining EPR and NMR 131
11 On Biological Information 143
12 Accuracy versus Efficacy in Biological Processes 147
13 Towards a Memory-Based Interpretation of Proteome Data 155
14 Modelling DNA Structure from Sequence 167
15 Nonlinear Dynamics in the Binary DNA/RNA Coding Problem 185
16 High Density DNA and Protein Arrays, Generation and Applications 195
17 Mechanisms of Synaptic Plasticity in the Brain 203
Subject Index 229
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