Surviving Hypoxia: Mechanisms of Control and Adaptation

by Peter W. Hochachka, Peter L. Lutz, Thomas J. Sick, Myron Rosenthal

Overview

Surviving Hypoxia: Mechanisms of Control and Adaptation is a synthesis of findings and thoughts concerning hypoxia. The thermodynamics of hypoxia are discussed in detail, including acid-base balance and self-pollution resulting from the accumulation of anaerobic end-products. The book focuses on descriptions and discussions of common facets, contrasting solutions in a variety of physiological hypoxia defense strategies, including those shown by plants, invertebrates, and vertebrates. Special treatment is given to the distinctive problems that hypoxia presents to vulnerable organs such as the kidney, liver, and brain. It also addresses pathological events in addition to protective mechanisms. Clinical implications of basic research are examined in the book, which provides new insights into underlying pathological processes occuring in hypoxic-induced organ failure and indicates new paths for successful clinical intervention. Surviving Hypoxia: Mechanisms of Control and Adaptation is an excellent reference for all researchers interested in the physiological effects of hypoxia, underlying pathological events, and protective mechanisms.

Product Details

ISBN-13:	9781000722031
Publisher:	CRC Press
Publication date:	11/30/2022
Sold by:	Barnes & Noble
Format:	eBook
Pages:	592
File size:	6 MB

About the Author

Peter William Hochachka, Ph.D., F.R.S.C., born in Bordenave, Alberta, obtained his formal training at the University of Alberta (Honors B.Sc.), Dalhousie University (M.Sc.), and Duke University (Ph.D. and Postdoctoral Fellowship). Peter L. Lutz, Ph.D., holds the McGinty Eminent Scholar Chair in Biology at Florida Atlantic University. Thomas J. Sick, Ph.D., is Professor of Neurology in the School of Medicine at the University of Miami and holds joint appointments in the Department of Physiology/Biophysics, and Marine Biology and Fisheries at the University of Miami Rosensteil School of Marine and Atmospheric Sciences. Myron Rosenthal, Ph.D., is Professor of Neurology and Physiology/Biophysics in the School of Medicine of the University of Miami. He also is Professor of Marine Biology and Fisheries at that university's Rosensteil School. Guido E.E.J.M. van den Thillart, Ph.D., is Associate Professor of Animal Physiology at the Department of Biology, University of Leiden, The Netherlands.

Table of Contents

Volume Overview: Hypoxia Defense and Adaptational Strategies PART I ADVANTAGEOUS BIOCHEMICAL PATHWAYS PART II HYPOXIA DEFENSE AND CONTROL SYSTEMS PART III MEMBRANE-METABOLISM INTERFACE Maintaining Coupled Metabolism and Membrane Function in Anoxic Brain: A Comparison Between the Turtle and Rat PART IV INTEGRATED SYSTEMS Hypoxia and Posthypoxic Recovery in Insects: Physiological and Metabolic Aspects PARTV RECOVERY Structural Effects of Intracellular Amino Acids During ATP Depletion SUMMARY The Technology Transfer Issue: From Hypoxia Research to the Clinical Researcher