Susceptibility to Infectious Diseases: The Importance of Host Genetics

Susceptibility to Infectious Diseases: The Importance of Host Genetics

by Richard Bellamy
     
 

ISBN-10: 0521129591

ISBN-13: 9780521129596

Pub. Date: 02/04/2010

Publisher: Cambridge University Press

This book summarises the advances that have been made in understanding the complexity of host genetic susceptibility. The diseases covered include those of great public health importance, such as malaria and HIV, and those of current topical interest, such as Creutzfeldt-Jakob disease. Many different techniques have been used to identify host genes involved in…  See more details below

Overview

This book summarises the advances that have been made in understanding the complexity of host genetic susceptibility. The diseases covered include those of great public health importance, such as malaria and HIV, and those of current topical interest, such as Creutzfeldt-Jakob disease. Many different techniques have been used to identify host genes involved in infectious disease susceptibility. Each chapter describes how these discoveries were made, and the book is therefore useful to anyone planning genetic studies on a multifactorial disease, regardless of whether it has an infectious etiology.

Product Details

ISBN-13:
9780521129596
Publisher:
Cambridge University Press
Publication date:
02/04/2010
Series:
Advances in Molecular and Cellular Microbiology Series, #4
Pages:
424
Product dimensions:
6.00(w) x 8.90(h) x 1.10(d)

Table of Contents

Contributors
1Introduction1
2Application of genetic epidemiology to dissecting host susceptibility/resistance to infection illustrated with the study of common mycobacterial infections7
3The diverse genetic basis of immunodeficiencies45
4Genetic diversity in the major histocompatibility complex and the immune response to infectious diseases77
5The cystic fibrosis transmembrane conductance regulator117
6The influence of inherited traits on malaria infection139
7Polymorphic chemokine receptor and ligand genes in HIV infection185
8NRAMP1 and resistance to intracellular pathogens221
9The interleukin-12/interferon-[gamma] loop is required for protective immunity to experimental and natural infections by Mycobacterium259
10Mannose-binding lectin deficiency and susceptibility to infectious disease279
11Blood group phenotypes and infectious diseases
12Genetics of human susceptibility to infection and hepatic disease caused by schistosomes
13Genetic susceptibility to prion diseases361
Index393

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