Syndromes of the Head and Neck

Syndromes of the Head and Neck

by Robert J. Gorlin, L. Stefan Levin, M. Michael Cohen
     
 


This classic text, one of the true anchors of our clinical genetics publishing program, covers over 700 different genetic syndromes involving the head and neck, and it has established itself as the definitive, comprehensive work on the subject. The discussion covers the phenotype spectrum, epidemiology, mode of inheritance, pathogenesis, and clinical profile of…  See more details below

Overview


This classic text, one of the true anchors of our clinical genetics publishing program, covers over 700 different genetic syndromes involving the head and neck, and it has established itself as the definitive, comprehensive work on the subject. The discussion covers the phenotype spectrum, epidemiology, mode of inheritance, pathogenesis, and clinical profile of each condition, all of which is accompanied by a wealth of illustrations. The authors are recognized leaders in the field, and their vast knowledge and strong clinical judgment will help readers make sense of this complex and burgeoning field.

Dr. Gorlin retires as editor in this edition and co-editor Raoul Hennekam takes over. Dr. Hennekam is regarded as one of the top dysmorphologists--and indeed one of the top clinical geneticists--in the world. Judith Allanson is new to the book but is a veteran OUP author and a widely respected geneticist, and Ian Krantz at Penn is a rising star in the field. Dr. Gorlin's name has always been closely associated with the book, and it has now become part of the title.

As in all fields of genetics, there has been an explosion in the genetics of dysmorphology syndromes, and the author has undertaken a complete updating of all chapters in light of the discoveries of the Human Genome Project and other ongoing advances, with some chapters requiring complete rewriting. Additional material has been added both in terms of new syndromes and in updating information on existing syndromes. The book will appeal to clinical geneticists, pediatricians, neurologists, head and neck surgeons, otolarynologists, and dentists. The 4th edition, which published in 2001, has sold 2,600 copies.

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Editorial Reviews

Doody's Review Service
Reviewer: Steven A. Battaglia, MD (Northwestern University Feinberg School of Medicine)
Description: The fourth edition of this dense, exhaustively referenced book on syndromes of the head and neck has expanded as a result of the explosion in medical genetics.
Purpose: At well over 1,000 pages, this is a standard reference textbook. This edition builds upon the mountain of knowledge in the previous edition, published in 1990. It succeeds as a comprehensive, single volume source for current information on clinical syndromes that feature craniofacial anomalies.
Audience: The book is designed to function as a reference for anyone who participates in the care of patients with syndromes of the head and neck. These patients are particularly complex and demand a multidisciplinary approach. As such, this edition is as valuable to the plastic surgeon approaching a child with a cleft palate as it is for the genetic counselor.
Features: All known syndromes that are characterized by craniofacial dysmorphism are included. The scope of knowledge is impressive; there are 350 discrete syndromes which feature some form of orofacial clefting. A particular strength are the hundreds of clinical photographs which cement the lengthy, technical descriptions of various phenotypes. There is a very practical appendix which includes not only measurements of use in evaluating the face and cranium, but also a list of websites and computerized database systems for practitioners seeking advice or more information.
Assessment: It is difficult to find fault with this book. Previous editions provided the phenotypic spectrum, epidemiology, mode of inheritance, and pathogenesis of many hundreds of syndromes. A decade of intensive research into the human genome has revealed the molecular basis for many anomalies, and these insights are featured prominently throughout. Herein lies its strength — and principal weakness. The correlation between genotype and phenotype is still lacking for many disorders, but the knowledge gap is closing rapidly. Although the pace of new discoveries in molecular biology renders any static text incomplete even before the ink dries, this book will certainly remain an authoritative source for years to come.

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Product Details

ISBN-13:
9780195045185
Publisher:
Oxford University Press, USA
Publication date:
06/28/1990
Series:
Oxford Monographs on Medical Genetics Series, #19
Edition description:
REV
Pages:
1008
Product dimensions:
9.25(w) x 14.25(h) x 2.36(d)

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